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Université de Fribourg

Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome

Pecze, Laszlo ; Randi, Elisa B. ; Szabo, Csaba

In: Molecular Medicine, 2020, vol. 26, no. 1, p. 102

Clinical observations and preclinical studies both suggest that Down syndrome (DS) may be associated with significant metabolic and bioenergetic alterations. However, the relevant scientific literature has not yet been systematically reviewed. The aim of the current study was to conduct a meta-analysis of metabolites involved in bioenergetics pathways in DS to conclusively determine the...

Université de Fribourg

Nondefective stationary discs and 2-jet determination in higher codimension

Bertrand, Florian ; Meylan, Francine

In: The Journal of Geometric Analysis, 2020, p. -

We discuss the links between stationary discs, the defect of analytic discs, and 2-jet determination of CR automorphisms of generic nondegenerate real submanifolds of CN of class C4.

Haute Ecole d'Ingénierie

Analyse des composés phénoliques dans les vins et dans les extraits de rafle par HPLC-DAD-MS

Lopez, Alexandro ; Kalman Franka (Dir.)

Mémoire de bachelor : Haute Ecole d'Ingénierie, 2019.

L’objectif du projet est d’établir une méthode analytique permettant de quantifier par DAD- FLD et potentiellement MS une partie des flavanols et des proanthocyanidines de type B et C présent dans les extraits de rafles et les vins.

Université de Fribourg

Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

Filseck, Joachim Moser von ; Čopič, Alenka ; Delfosse, Vanessa ; Vanni, Stefano ; Jackson, Catherine L. ; Bourguet, William ; Drin, Guillaume

In: Science, 2015, vol. 349, no. 6246, p. 432–436

In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum (ER) but is highly enriched in the plasma membrane (PM), where it contributes negative charge and to specific recruitment of signaling proteins. This distribution relies on transport mechanisms whose nature remains elusive. Here, we found that the PS transporter Osh6p extracted phosphatidylinositol...

Université de Fribourg

Mitochondrial sphingosine-1-phosphate lyase is essential for phosphatidylethanolamine synthesis and survival of Trypanosoma brucei

Dawoody Nejad, Ladan ; Stumpe, Michael ; Rauch, Monika ; Hemphill, Andrew ; Schneiter, Roger ; Bütikofer, Peter ; Serricchio, Mauro

In: Scientific Reports, 2020, vol. 10, no. 1, p. 8268

Sphingosine-1-phosphate is a signaling molecule involved in the control of cell migration, differentiation, survival and other physiological processes. This sphingolipid metabolite can be degraded by the action of sphingosine-1-phosphate lyase (SPL) to form hexadecenal and ethanolamine phosphate. The importance of SPL-mediated ethanolamine phosphate formation has been characterized in only...

Université de Fribourg

Stationary distributions and condensation in autocatalytic reaction networks

Hoessly, Linard ; Mazza, Christian

In: SIAM Journal on Applied Mathematics, 2019, vol. 79, no. 4, p. 1173–1196

We investigate a broad family of stochastically modeled reaction networks by looking at their stationary distributions. Most known results on stationary distributions assume weak reversibility and zero deficiency. We first explicitly give product-form stationary distributions for a class of mostly non-weakly-reversible autocatalytic reaction networks of arbitrary deficiency. We provide...

Consortium of Swiss Academic Libraries

More Than Charged Base Loss — Revisiting the Fragmentation of Highly Charged Oligonucleotides

Nyakas, Adrien ; Eberle, Rahel ; Stucki, Silvan ; Schürch, Stefan

In: Journal of The American Society for Mass Spectrometry, 2014, vol. 25, no. 7, p. 1155-1166

Haute Ecole d'Ingénierie

3D profile reconstruction

Briguet, Daniel ; Kandaswamy, Djano (Dir.)

Mémoire de bachelor : Haute Ecole d'Ingénierie, 2018.

The objective of the project is to develop a system to reconstruct in 3D the profile of a moving object.