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Université de Fribourg

Gene expression analysis in the mouse brainstem identifies Cart and Nesfatin as neuropeptides coexpressed in the Calbindin-positive neurons of the Nucleus papilio

Girard, Franck ; von Siebenthal, Michelle ; Davis, Fred P. ; Celio, Marco R.

In: Sleep, 2020, vol. 43, no. 2020-11, p. zsaa085

Study Objectives: The brainstem contains several neuronal populations, heterogeneous in terms of neurotransmitter/neuropeptide content, which are important for controlling various aspects of the rapid eye movement (REM) phase of sleep. Among these populations are the Calbindin (Calb)-immunoreactive NPCalb neurons, located in the Nucleus papilio, within the dorsal paragigantocellular nucleus...

Université de Fribourg

Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

Janickova, Lucia ; Rechberger, Karin Farah ; Wey, Lucas ; Schwaller, Beat

In: Molecular Autism, 2020, vol. 11, no. 1, p. 47

In fast firing, parvalbumin (PV)-expressing (Pvalb) interneurons, PV acts as an intracellular Ca2+ signal modulator with slow-onset kinetics. In Purkinje cells of PV−/− mice, adaptive/homeostatic mechanisms lead to an increase in mitochondria, organelles equally capable of delayed Ca2+ sequestering/buffering. An inverse regulation of PV and mitochondria likewise operates in cell model...

Université de Fribourg

Neurons in the Nucleus papilio contribute to the control of eye movements during REM sleep

Gutierrez Herrera, C. ; Girard, Franck ; Bilella, Alessandro ; Gent, T. C. ; Roccaro-Waldmeyer, Diana M. ; Adamantidis, A. ; Celio, Marco R.

In: Nature Communications, 2019, vol. 10, no. 1, p. 1–11

Rapid eye movements (REM) are characteristic of the eponymous phase of sleep, yet the underlying motor commands remain an enigma. Here, we identified a cluster of Calbindin-D28K-expressing neurons in the Nucleus papilio (NPCalb), located in the dorsal paragigantocellular nucleus, which are active during REM sleep and project to the three contralateral eye-muscle nuclei. The firing of...

Université de Fribourg

Distribution and restoration of serotonin-immunoreactive paraneuronal cells during caudal fin regeneration in zebrafish

König, Désirée ; Dagenais, Paule ; Senk, Anita ; Djonov, Valentin ; Aegerter, Christof M. ; Jaźwińska, Anna

In: Frontiers in Molecular Neuroscience, 2019, vol. 12, p. -

Aquatic vertebrates possess diverse types of sensory cells in their skin to detect stimuli in the water. In the adult zebrafish, a common model organism, the presence of such cells in fins has only rarely been studied. Here, we identified scattered serotonin (5-HT)-positive cells in the epidermis of the caudal fin. These cells were distinct from keratinocytes as revealed by their low...

Université de Fribourg

The orbitofrontal cortex projects to the parvafox nucleus of the ventrolateral hypothalamus and to its targets in the ventromedial periaqueductal grey matter

Babalian, Alexandre ; Eichenberger, Simone ; Bilella, Alessandro ; Girard, Franck ; Szabolcsi, Viktoria ; Roccaro, Diana ; Alvarez-Bolado, Gonzalo ; Xu, Chun ; Celio, Marco R.

In: Brain Structure and Function, 2019, vol. 224, no. 1, p. 293–314

Although connections between the orbitofrontal cortex (OFC)—the seat of high cognitive functions—the lateral hypothalamus and the periaqueductal grey (PAG) have been recognized in the past, the precise targets of the descending fibres have not been identified. In the present study, viral tracer-transport experiments revealed neurons of the lateral (LO) and the ventrolateral (VLO) OFC...

Université de Fribourg

Characterization and potential roles of calretinin in rodent spermatozoa

Dressen, Cindy ; Schwaller, Beat ; Vegh, Grégory ; Leleux, Fabienne ; Gall, David ; Lebrun, Philippe ; Lybaert, Pascale

In: Cell Calcium, 2018, vol. 74, p. 94–101

Calretinin has been detected in various excitable cells but the presence and putative roles of such a calcium-binding protein has never been characterized in sperm.Epididymal spermatozoa were collected from C57Bl6 (wild-type, WT) or calretinin knockout (CR−/−) mice and Wistar rats. A specific staining for calretinin was detected by immunofluorescence in the principal piece of the...

Université de Fribourg

Absence of calretinin protein expression in malignant mesotheliomas from asbestos-exposed NF2+/− mice and mouse mesothelioma cell lines from various mouse strains

Blum, Walter ; Henzi, Thomas ; Châtel-Soulet, Hugues-Etienne ; Pecze, Laszlo ; Wörthmüller Rodriguez, Janine ; Vrugt, Bart ; Schwaller, Beat

In: Biomarker Research, 2018, vol. 6, no. 1, p. 19

Calretinin is the most widespread positive marker for the immunohistochemical identification of malignant mesothelioma (MM) and was proposed to serve as a blood- based biomarker. Functionally, evidence has accumulated that calretinin might be implicated in MM tumorigenesis. We aimed to identify calretinin (CR; Calb2) in murine MM and reactive mesothelial cells in granuloma from...

Université de Fribourg

Dysregulation of parvalbumin expression in the Cntnap2−/− mouse model of autism spectrum disorder

Lauber, Emanuel ; Filice, Federica ; Schwaller, Beat

In: Frontiers in Molecular Neuroscience, 2018, vol. 11, p. -

Due to the complex and heterogeneous etiology of autism spectrum disorder (ASD), identification of convergent pathways and/or common molecular endpoints in the pathophysiological processes of ASD development are highly needed in order to facilitate treatment approaches targeted at the core symptoms. We recently reported on decreased expression of the Ca2+-binding protein parvalbumin (PV) in...