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Université de Fribourg

Beyond global charge: role of amine bulkiness and protein fingerprint on nanoparticle–cell interaction

Burnand, David ; Milosevic, Ana ; Balog, Sandor ; Spuch-Calvar, Miguel ; Rothen-Rutishauser, Barbara ; Dengjel, Jörn ; Kinnear, Calum ; Moore, Thomas L. ; Petri-Fink, Alke

In: Small, 2018, vol. 14, no. 46, p. 1802088

Amino groups presented on the surface of nanoparticles are well‐known to be a predominant factor in the formation of the protein corona and subsequent cellular uptake. However, the molecular mechanism underpinning this relationship is poorly defined. This study investigates how amine type and density affect the protein corona and cellular association of gold nanoparticles with cells in...

Université de Fribourg

Carbon nanodots: Opportunities and limitations to study their biodistribution at the human lung epithelial tissue barrier

Durantie, Estelle ; Barosova, Hana ; Drasler, Barbara ; Rodriguez-Lorenzo, Laura ; Urban, Dominic A. ; Vanhecke, Dimitri ; Septiadi, Dedy ; Hirschi-Ackermann, Liliane ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Biointerphases, 2018, vol. 13, no. 6, p. 06D404

Inhalation of combustion-derived ultrafine particles (≤0.1 μm) has been found to be associated with pulmonary and cardiovascular diseases. However, correlation of the physicochemical properties of carbon-based particles such as surface charge and agglomeration state with adverse health effects has not yet been established, mainly due to limitations related to the detection of carbon...

Université de Fribourg

Synthesis of telechelic poly(p-benzamide)s

Alizadeh, Mahshid ; Kilbinger, Andreas F. M.

In: Macromolecules, 2018, vol. 51, no. 11, p. 4363–4369

Well-defined telechelic poly(benzamide)s were synthesized by chain-growth polycondensation of phenyl-4-amino benzoate and pentafluorophenyl-4-amino benzoate derivatives with a bifunctional initiator in the presence of LiTMP as base. The polymerization was carried out at −70 °C to prevent self-initiated polymerization. To confirm the control over molecular weight, different defined...

Université de Fribourg

Distribution of polymer-coated gold nanoparticles in a 3D lung model and indication of apoptosis after repeated exposure

Chortarea, Savvina ; Fytianos, Kleanthis ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: Nanomedicine, 2018, vol. 13, no. 10, p. 1169–1185

Aim: The distribution and impact of aerosol-delivered gold nanoparticles (AuNPs) functionalized with a mixture of aminated-polyvinyl alcohol and amino-PEG ([polyvinyl alcohol/PEG]-NH2) upon repeated administration onto a 3D lung model were explored. Materials & methods: AuNPs were aerosolized and uptake and epithelial translocation was assessed by inductively coupled plasma optical-emission ...

Consortium of Swiss Academic Libraries

Conformation-Specific Spectroscopy of Peptide Fragment Ions in a Low-Temperature Ion Trap

Wassermann, Tobias ; Boyarkin, Oleg ; Paizs, Béla ; Rizzo, Thomas

In: Journal of The American Society for Mass Spectrometry, 2012, vol. 23, no. 6, p. 1029-1045