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Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance

Galimov, Artur ; Hartung, Angelika ; Trepp, Roman ; Mader, Alexander ; Flück, Martin ; Linke, Axel ; Blüher, Matthias ; Christ, Emanuel ; Krützfeldt, Jan

In: Journal of Molecular Medicine, 2015, vol. 93, no. 12, p. 1369-1379

FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase

Imeri, Faik ; Blanchard, Olivier ; Jenni, Aurelio ; Schwalm, Stephanie ; Wünsche, Christin ; Zivkovic, Aleksandra ; Stark, Holger ; Pfeilschifter, Josef ; Huwiler, Andrea

In: Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, vol. 388, no. 12, p. 1283-1292

Myosin 1b regulates nuclear AKT activation by preventing localization of PTEN in the nucleus

Yu, Yi ; Xiong, Yuyan ; Ladeiras, Diogo ; Yang, Zhihong ; Ming, Xiu-Fen

In: iScience, 2019, vol. 19, p. 39–53

Insulin-induced AKT activation is dependent on phosphoinositide 3-kinase and opposed by tumor suppressor phosphatase and tensin homolog (PTEN). Our previous study demonstrates that myosin 1b (MYO1B) mediates arginase-II-induced activation of mechanistic target of rapamycin complex 1 that is regulated by AKT. However, the role of MYO1B in AKT activation is unknown. Here we show that silencing...

Hypoxia refines plasticity of mitochondrial respiration to repeated muscle work

Desplanches, Dominique ; Amami, Myriam ; Dupré-Aucouturier, Sylvie ; Valdivieso, Paola ; Schmutz, Silvia ; Mueller, Matthias ; Hoppeler, Hans ; Kreis, Roland ; Flück, Martin

In: European Journal of Applied Physiology, 2014, vol. 114, no. 2, p. 405-417

Capsule Commentary on Patrick et al., Trends in Insulin Initiation and Treatment Intensification among Patients with Type 2 Diabetes

Jornayvaz, François

In: Journal of General Internal Medicine, 2014, vol. 29, no. 2, p. 356-356

Insulin secretion response during oral glucose tolerance test is related to low cardiorespiratory fitness in obese adolescents

Maggio, Albane B.R. ; Bou Puigdefabregas, Julie Wacker ; Schwitzgebel, Valerie M. ; Chamay-Weber, Catherine ; Beghetti, Maurice ; Farpour-Lambert, Nathalie J.

In: Journal of Pediatric Endocrinology and Metabolism, 2015, vol. 28, no. 5-6, p. 539-544

Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Vogl, Claus ; Flatt, Thomas ; Fuhrmann, Bernd ; Hofmann, Elisabeth ; Wallner, Barbara ; Stiefvater, Rita ; Kovarik, Pavel ; Strobl, Birgit ; Müller, Mathias

In: BMC Genomics, 2010, vol. 11, no. 199, p. 1-19

Background: Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate immunity and inflammation. Mice lacking Tyk2 are resistant to endotoxin shock induced by lipopolysaccharide (LPS), and Tyk2 deficient macrophages fail to efficiently induce interferon alpha/beta after LPS treatment....

Phosphoinositides and Charcot-Marie-Tooth disease: New keys to old questions

Suter, U.

In: Cellular and Molecular Life Sciences, 2007, vol. 64, no. 24, p. 3261-3265

Association between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus

Simeoni, E. ; Hoffmann, M. ; Winkelmann, B. ; Ruiz, J. ; Fleury, S. ; Boehm, B. ; März, W. ; Vassalli, G.

In: Diabetologia, 2004, vol. 47, no. 9, p. 1574-1580

Fuel metabolism during exercise in euglycaemia and hyperglycaemia in patients with type 1 diabetes mellitus—a prospective single-blinded randomised crossover trial

Jenni, S. ; Oetliker, C. ; Allemann, S. ; Ith, M. ; Tappy, L. ; Wuerth, S. ; Egger, A. ; Boesch, C. ; Schneiter, Ph ; Diem, P. ; Christ, E. ; Stettler, C.

In: Diabetologia, 2008, vol. 51, no. 8, p. 1457-1465