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Université de Fribourg

Cutaneous inputs to dorsal column nuclei in adult macaque monkeys subjected to unilateral lesion of the primary motor cortex or of the cervical spinal cord and treatments promoting axonal growth

Savidan, Julie ; Beaud, Marie-Laure ; Rouiller, Eric M.

In: Neuroscience Insights, 2020, vol. 15, p. 2633105520973991

The highly interconnected somatosensory and motor systems are subjected to connectivity changes at close or remote locations following a central nervous system injury. What is the impact of unilateral injury of the primary motor cortex (hand area; MCI) or of the cervical cord (hemisection at C7-C8 level; SCI) on the primary somatosensory (cutaneous) inputs to the dorsal column nuclei (DCN) in...

Université de Fribourg

Variable interhemispheric asymmetry in layer v of the supplementary motor area following cervical hemisection in adult macaque monkeys

Contestabile, Alessandro ; Colangiulo, R. ; Lucchini, Matteo ; Rouiller, Eric M. ; Schmidlin, Eric

In: eNeuro, 2020, vol. 7, no. 5, p. ENEURO.0280-20.2020

Motor cortical areas from both hemispheres play a role during functional recovery after a unilateral spinal cord injury (SCI). However, little is known about the morphologic and phenotypical differences that a SCI could trigger in corticospinal (CS) neurons of the ipsilesional and contralesional hemisphere. Using an SMI-32 antibody which specifically labeled pyramidal neurons in cortical...

Université de Fribourg

Cortical projection from the premotor or primary motor cortex to the subthalamic nucleus in intact and parkinsonian adult macaque monkeys: a pilot tracing study

Borgognon, Simon ; Cottet, Jérôme ; Badoud, Simon ; Bloch, Jocelyne ; Brunet, Jean-François ; Rouiller, Eric M.

In: Frontiers in Neural Circuits, 2020, vol. 14, p. -

Besides the main cortical inputs to the basal ganglia, via the corticostriatal projection, there is another input via the corticosubthalamic projection (CSTP), terminating in the subthalamic nucleus (STN). The present study investigated and compared the CSTPs originating from the premotor cortex (PM) or the primary motor cortex (M1) in two groups of adult macaque monkeys. The first group...

Université de Fribourg

Reward-related suppression of neural activity in macaque visual area v4

Shapcott, Katharine A ; Schmiedt, Joscha T ; Kouroupaki, Kleopatra ; Kienitz, Ricardo ; Lazar, Andreea ; Singer, Wolf ; Schmid, Michael C

In: Cerebral Cortex, 2020, vol. 30, no. 9, p. 4871–4881

In order for organisms to survive, they need to detect rewarding stimuli, for example, food or a mate, in a complex environment with many competing stimuli. These rewarding stimuli should be detected even if they are nonsalient or irrelevant to the current goal. The value-driven theory of attentional selection proposes that this detection takes place through reward-associated stimuli...