In: European Archives of Psychiatry and Clinical Neuroscience, 2015, vol. 265, no. 8, p. 637-645
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In: Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, vol. 388, no. 1, p. 43-49
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In: Journal of Analytical Toxicology, 2018, vol. 42, no. 6, p. 365-374
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In: Sleep, 2016, vol. 39, no. 6, p. 1305-1310
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In: Journal of Molecular Biology, 2020, vol. 432, no. 12, p. 3714–3721
The circadian system consists of individual cellular clocks. It organizes and synchronizes biochemical and physiological processes in order to optimally adapt an organism to its environment. This requires that the circadian system is responsive to environmental cues, which contain information about geophysical time (e.g., light), and allows an organism to predict daily recurring events....
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In: eLife, 2019, vol. 8, p. e50925
Circadian oscillations emerge from transcriptional and post-translational feedback loops. An important step in generating rhythmicity is the translocation of clock components into the nucleus, which is regulated in many cases by kinases. In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2) is unknown. Here, we show that the cyclin-dependent kinase 5...
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In: Cell Metabolism, 2019, vol. 30, no. 2, p. 238–250
The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This...
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In: Journal of Anesthesia, 2014, vol. 28, no. 4, p. 580-586
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In: Trends in Neurosciences, 2018, vol. 41, no. 10, p. 677–688
The rotation of the Earth around its axis causes periodic exposure of half of its surface to sunlight. This daily recurring event has been internalized in most organisms in the form of cellular circadian clock mechanisms. These cellular clocks are synchronized with each other in various ways to establish circadian networks that build the circadian program in tissues and organs, coordinating...
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In: Canadian Journal of Anesthesia, 2005, vol. 52, no. 8, p. 806-821
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