In: Human Molecular Genetics, 2017, vol. 26, no. 3, p. 582-598
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In: Zoological Journal of the Linnean Society, 2016, vol. 177, no. 3, p. 541-557
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In: Integrative and Comparative Biology, 2018, vol. 58, no. 3, p. 532-543
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In: Toxicological Sciences, 2017, vol. 157, no. 1, p. 183-195
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In: Antioxidants & Redox Signaling, 2021, vol. 34, no. 16, p. 1280-1318
Significance: Cytochrome bd is a ubiquinol:oxygen oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role is to couple the reduction of molecular oxygen, even at submicromolar concentrations, to water with the generation of a proton motive force used for adenosine triphosphate production. Cytochrome bd is found in many ...
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In: PLOS Genetics, 2016, vol. 12, no. 12, p. e1006499
Heritable DNA methylation imprints are ubiquitous and underlie genetic variability from bacteria to humans. In microbial genomes, DNA methylation has been implicated in gene transcription, DNA replication and repair, nucleoid segregation, transposition and virulence of pathogenic strains. Despite the importance of local (hypo)methylation at specific loci, how and when these patterns are...
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In: Genome Biology and Evolution, 2020, vol. 12, no. 7, p. 1167–1173
Rapid evolution of weed biological control agents (BCAs) to new biotic and abiotic conditions is poorly understood and so far only little considered both in pre-release and post-release studies, despite potential major negative or positive implications for risks of nontargeted attacks or for colonizing yet unsuitable habitats, respectively. Provision of genetic resources, such as assembled...
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In: The EMBO Journal, 2020, vol. 39, no. 19, p. e103889
Plasticity of the proteome is critical to adapt to varying conditions. Control of mitochondrial protein import contributes to this plasticity. Here, we identified a pathway that regulates mitochondrial protein import by regulated N-terminal processing. We demonstrate that dipeptidyl peptidases 8/9 (DPP8/9) mediate the N-terminal processing of adenylate kinase 2 (AK2) en route to mitochondria....
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In: Molecular Autism, 2020, vol. 11, no. 1, p. 47
In fast firing, parvalbumin (PV)-expressing (Pvalb) interneurons, PV acts as an intracellular Ca2+ signal modulator with slow-onset kinetics. In Purkinje cells of PV−/− mice, adaptive/homeostatic mechanisms lead to an increase in mitochondria, organelles equally capable of delayed Ca2+ sequestering/buffering. An inverse regulation of PV and mitochondria likewise operates in cell model...
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In: Scientific Reports, 2019, vol. 9, no. 1, p. 10603
Forebrain glial cells - ependymal cells and astrocytes -acquire upon injury- a “reactive” phenotype associated with parvalbumin (PV) upregulation. Since free radicals, e.g. reactive oxygen species (ROS) play a role in the pathogenesis of multiple sclerosis, and that PV-upregulation in glial cells is inversely correlated with the level of oxidative stress, we hypothesized that...
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