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Université de Fribourg

Alpha-helical folding of SilE models upon Ag(His)(Met) motif formation

Chabert, Valentin ; Hologne, Maggy ; Sénèque, Olivier ; Walker, Olivier ; Fromm, Katharina M.

In: Chemical Communications, 2018, vol. 54, no. 74, p. 10419–10422

The SilE protein is suspected to have a prominent role in Ag+ detoxification of silver resistant bacteria. Using model peptides, we elucidated both qualitative and quantitative aspects of the Ag+-induced α-helical structuring role of His- and Met-rich sequences of SilE, improving our understanding of its function within the Sil system.

Université de Fribourg

Mimicking the chemistry of natural eumelanin synthesis: the ke sequence in polypeptides and in proteins allows for a specific control of nanosized functional polydopamine formation

Bergtold, Camille ; Hauser, Daniel ; Alain Chaumont ; El Yakhlifi, Salima ; Mateescu, Mihaela ; Meyer, Florent ; Metz-Boutigue, Marie-Hélène ; Benoît Frisch ; Schaaf, Pierre ; Ihiawakrim, Dris ; Ersen, Ovidiu ; Monnier, Christophe A. ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara ; Ball, Vincent

In: Biomacromolecules, 2018, vol. 19, no. 9, p. 3693–3704

The oxidation of dopamine and of other catecholamines leads to the formation of conformal films on the surface of all known materials and to the formation of a precipitate in solution. In some cases, it has been shown that the addition of additives in the dopamine solution, like certain surfactants or polymers, polyelectrolytes, and certain proteins, allows to get polydopamine nanoparticles...

Université de Fribourg

DFT investigation of methane metathesis with L2AnCH3 actinide complexes catalysts (L = Cl, Cp, Cp*; An = Ac, Th, Pa, U, Np, Pu)

Talbi-Ingrachen, Fazia ; Talbi, Fatiha ; Kias, Farida ; Elkechai, Aziz ; Boucekkine, Abdou ; Daul, Claude

In: Computational and Theoretical Chemistry, 2018, vol. 1138, p. 123–134

In order to understand the catalytic activity of the actinide complexes L2AnCH3 (An = Ac, Th, Pa, U, Np and Pu; L = Cl, Cp and Cp∗) towards the activation of the CH bond of methane, relativistic ZORA/DFT investigations have been carried out. The results obtained from Linear Transit (LT) and Intrinsic Reaction Coordinate (IRC) calculations show that the mechanism involved in these...

Université de Fribourg

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

Rita, Anthea Di ; Peschiaroli, Angelo ; D?Acunzo, Pasquale ; Strobbe, Daniela ; Hu, Zehan ; Gruber, Jens ; Nygaard, Mads ; Lambrughi, Matteo ; Melino, Gerry ; Papaleo, Elena ; Dengjel, Jörn ; Alaoui, Said El ; Campanella, Michelangelo ; Dötsch, Volker ; Rogov, Vladimir V. ; Strappazzon, Flavie ; Cecconi, Francesco

In: Nature Communications, 2018, vol. 9, no. 1, p. 3755

The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 regulator-1) has been defined as a novel regulator of mitophagy in both PINK1/PARKIN-dependent and -independent systems. Here, we identified the E3...

Université de Fribourg

Genetic and Functional Characterization of an MCR-3-Like Enzyme-Producing Escherichia coli Isolate Recovered from Swine in Brazil

Kieffer, Nicolas ; Nordmann, Patrice ; Moreno, Andrea Micke ; Zanolli Moreno, Luisa ; Chaby, Richard ; Breton, Aude ; Tissières, Pierre ; Poirel, Laurent

In: Antimicrobial Agents and Chemotherapy, 2018, vol. 62, no. 7, p. e00278-18

A collection of 126 pigs was screened for carriage of colistin-resistant Enterobacteriaceae in a farm in Minas Gerais, Brazil. Out of this collection, eight colistin-resistant Escherichia coli isolates were recovered, including one from Minas Gerais State producing a new MCR-3 variant (MCR-3.12). Analysis of the lipopolysaccharide revealed that MCR-3.12 had a function similar to that of MCR-1...

Université de Fribourg

Biochronological and palaeobiogeographical significance of the earliest Miocene mammal fauna from Northern Vietnam

Antoine, Pierre-Olivier ; Made, Jan van der ; Métais, Grégoire ; Phuc, Laq The ; Quan, Quý Tr??ng ; Schneider, Simon ; Tran, Dang Ngoc ; Vasilyan, Davit ; Viet, Luong The ; Böhme, Madelaine

In: Palaeobiodiversity and Palaeoenvironments, 2018, vol. 98, no. 2, p. 287–313

Current scientific knowledge of Tertiary fossils from south of the Ailao Shan-Red River shear zone is extremely poor, in sharp contrast with the situation nowadays, as the area of Laos and Vietnam is regarded as a global hotspot of biodiversity. In this context, the few localities that yielded fossil assemblages are of first importance for the understanding of Cenozoic palaeobiogeography and...

Université de Fribourg

A description of the skull of eubaena cephalica (hay, 1904) and new insights into the cranial circulation and innervation of baenid turtles

Rollot, Yann ; Lyson, Tyler R. ; Joyce, Walter G.

In: Journal of Vertebrate Paleontology, 2018, vol. 38, no. 3, p. e1474886

The internal carotid system has played an important role in the systematics of fossil turtles, including baenids. A new, almost perfectly preserved specimen of Eubaena cephalica provides an opportunity to explore for the first time the cranial circulation and innervation of this taxon using CT (computed tomography) scans. We here document that the skull possesses a well-developed, branching...

Université de Fribourg

Structures and activities of tiahuramides A–C, cyclic depsipeptides from a tahitian collection of the marine cyanobacterium Lyngbya majuscula

Levert, Annabel ; Alvariño, Rebeca ; Bornancin, Louis ; Mansour, Eliane Abou ; Burja, Adam M. ; Genevière, Anne-Marie ; Bonnard, Isabelle ; Alonso, Eva ; Botana, Luis ; Banaigs, Bernard

In: Journal of Natural Products, 2018, vol. 81, no. 6, p. 1301–1310

The structures of three new cyclic depsipeptides, tiahuramides A (1), B (2), and C (3), from a French Polynesian collection of the marine cyanobacterium Lyngbya majuscula are described. The planar structures of these compounds were established by a combination of mass spectrometry and 1D and 2D NMR experiments. Absolute configurations of natural and nonproteinogenic amino acids were...

Accès public à partir du 1 mars 2019
Université de Neuchâtel

First uncertainty evaluation of the FoCS-2 primary frequency standard

Jallageas, Antoine ; Devenoges, Laurent ; Petersen, M ; Morel, J ; Bernier, L. G ; Schenker, Dominique ; Thomann, Pierre ; Südmeyer, Thomas

In: Metrologia, 2018, vol. 55, no. 3, p. 366-385

We report the uncertainty evaluation of the Swiss continuous primary frequency standard FoCS-2 (Fontaine Continue Suisse). Unlike other primary frequency standards which are working with clouds of cold atoms, this fountain uses a continuous beam of cold caesium atoms bringing a series of metrological advantages and specific techniques for the evaluation of the uncertainty budget. Recent...

Université de Neuchâtel

Explicitation sequences in conversation: some considerations on formulations, candidate inferences and grounding

Chernyshova, Elizaveta

In: Revue Tranel, 2018, vol. 68, p. 51-58

This conversation analysis study focuses on sequences where speakers make a piece of information explicit (explicitation sequences). Among others, formulations (Heritage & Watson 1979) and candidate inferences (turns submitting an inference and requiring a confirmation in a second position) can initiate an explicitation. Based on a short analysis of conversational data in French this study shows...