In: Journal of Infection, 2020, vol. 81, no. 1, p. 17–47
Breastfeeding is associated with considerable health benefits for infants. Aside from essential nutrients, immune cells and bioactive components, breast milk also contains a diverse range of microbes, which are important for maintaining mammary and infant health. In this review, we summarise studies that have investigated the composition of the breast milk microbiota and factors that might...
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In: BMJ Open, 2020, vol. 10, no. 6, p. e036275
Introduction: There is compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. Antibiotics cause profound changes in the microbiome. However, the effect of intrapartum and early-life antibiotics on the maternal intestinal and breast milk microbiome, and the infant oral and intestinal microbiome, and whether...
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In: iScience, 2020, vol. 23, no. 3, p. 100932
Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show that granzyme B degrades multiple secreted virulence mediators from Listeria monocytogenes,...
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In: The Journal of Immunology, 2020, vol. 204, no. 7, p. 1798–1809
Plasmodium spp., the causative agent of malaria, have a complex life cycle. The exponential growth of the parasites during the blood stage is responsible for almost all malaria-associated morbidity and mortality. Therefore, tight immune control of the intraerythrocytic replication of the parasite is essential to prevent clinical malaria. Despite evidence that the particular lymphocyte subset ...
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In: Current Microbiology, 2014, vol. 68, no. 4, p. 419-427
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In: Nutrients, 2018, vol. 10, no. 9, p. 1230
Human milk has been previously found to contain various types of leukocytes however specific characteristics of these cells, such as whether they contain cytolytic antimicrobial proteins that may induce pathogen directed cell death, are unknown. This project aims to examine the presence and localization of immune proteins such as perforin, granulysin and granzymes in human milk cells at the...
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In: World Journal of Surgery, 2009, vol. 33, no. 3, p. 558-566
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In: The Journal of Membrane Biology, 2006, vol. 212, no. 1, p. 29-39
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In: European Journal of Clinical Microbiology and Infectious Diseases, 1998, vol. 17, no. 8, p. 597-599
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In: Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 12, p. 2651-2668
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