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Statistical structure of neural spiking under non-Poissonian or other non-white stimulation

Schwalger, Tilo ; Droste, Felix ; Lindner, Benjamin

In: Journal of Computational Neuroscience, 2015, vol. 39, no. 1, p. 29-51

Sugar-sensitive neurone responses and sugar feeding preferences influence lifespan and biting behaviours of the Afrotropical malaria mosquito, Anopheles gambiae

Kessler, Sébastien ; Vlimant, Michèle ; Guerin, Patrick

In: Journal of Comparative Physiology A, 2015, vol. 201, no. 3, p. 317-329

Quantifying the distribution of critical metals in conventional passenger vehicles using input-driven and output-driven approaches: a comparative study

Du, Xiaoyue ; Restrepo, Eliette ; Widmer, Rolf ; Wäger, Patrick

In: Journal of Material Cycles and Waste Management, 2015, vol. 17, no. 2, p. 218-228

Layer-Dependent Short-Term Synaptic Plasticity Between Excitatory Neurons in the C2 Barrel Column of Mouse Primary Somatosensory Cortex

Lefort, Sandrine ; Petersen, Carl C.H.

In: Cerebral Cortex, 2017, vol. 27, no. 7, p. 3869-3878

Bayes optimal template matching for spike sorting - combining fisher discriminant analysis with optimal filtering

Franke, Felix ; Quian Quiroga, Rodrigo ; Hierlemann, Andreas ; Obermayer, Klaus

In: Journal of Computational Neuroscience, 2015, vol. 38, no. 3, p. 439-459

GLUT2, glucose sensing and glucose homeostasis

Thorens, Bernard

In: Diabetologia, 2015, vol. 58, no. 2, p. 221-232

Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout.

Gáliková, Martina ; Flatt, Thomas

In: Aging, 2010, vol. 2, no. 7, p. 387-389

Dietary restriction (DR), reduced food uptake without malnutrition, is the most universal intervention known to extend animal lifespan, from invertebrates to mammals [1]. However, despite impressive progress in identifying the key components of the DR pathway, many proximal effectors of DR induced longevity remain unknown to date [1]. One central obstacle in the search for such mechanisms is...

Diet and longevity in the balance

Flatt, Thomas

In: Nature, 2009, vol. 462, no. 24, p. 989-990

Dietary restriction promotes longevity but impairs fecundity in many organisms. When the amino acids in a diet are fine-tuned, however, lifespan can be increased without loss of fecundity — at least in fruitflies.

Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span

Garschall, Kathrin ; Dellago, Hanna ; Gáliková, Martina ; Schosserer, Markus ; Flatt, Thomas ; Grillari, Johannes

In: npj Aging and Mechanisms of Disease, 2017, vol. 3, no. 1, p. 5

Mechanisms that ensure and maintain the stability of genetic information are fundamentally important for organismal function and can have a large impact on disease, aging, and life span. While a multi-layered cellular apparatus exists to detect and respond to DNA damage, various insults from environmental and endogenous sources continuously affect DNA integrity. Over time this can lead to the...

Reproductive and post-reproductive life history of wild-caught Drosophila melanogaster under laboratory conditions

Klepsatel, P. ; Gáliková, M. ; De Maio, N. ; Ricci, S. ; Schlötterer, C. ; Flatt, Thomas

In: Journal of Evolutionary Biology, 2013, vol. 26, no. 7, p. 1508–1520

The life history of the fruit fly (Drosophila melanogaster) is well understood, but fitness components are rarely measured by following single individuals over their lifetime, thereby limiting insights into lifetime reproductive success, reproductive senescence and post‐reproductive lifespan. Moreover, most studies have examined long‐ established laboratory strains rather than freshly...