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Université de Fribourg

Antimicrobial Resistance in Escherichia coli

Poirel, Laurent ; Madec, Jean-Yves ; Lupo, Agnese ; Schink, Anne-Kathrin ; Kieffer, Nicolas ; Nordmann, Patrice ; Schwarz, Stefan

In: Microbiology Spectrum, 2018, vol. 6, no. 4, p. -

Multidrug resistance in Escherichia coli has become a worrying issue that is increasingly observed in human but also in veterinary medicine worldwide. E. coli is intrinsically susceptible to almost all clinically relevant antimicrobial agents, but this bacterial species has a great capacity to accumulate resistance genes, mostly through horizontal gene transfer. The most problematic...

Université de Fribourg

Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis

Bibli, Sofia-Iris ; Hu, Jiong ; Sigala, Fragiska ; Wittig, Ilka ; Heidler, Juliana ; Zukunft, Sven ; Tsilimigras, Diamantis I. ; Randriamboavonjy, Voahanginirina ; Wittig, Janina ; Kojonazarov, Baktybek ; Schürmann, Christoph ; Siragusa, Mauro ; Siuda, Daniel ; Luck, Bert ; Malik, Randa Abdel ; Filis, Konstantinos A. ; Zografos, George ; Chen, Chen ; Wang, Dao Wen ; Pfeilschifter, Josef ; Brandes, Ralf P. ; Szabo, Csaba ; Papapetropoulos, Andreas ; Fleming, Ingrid

In: Circulation, 2019, vol. 139, no. 1, p. 101–114

Hydrogen sulfide (H2S), generated by cystathionine γ lyase (CSE), is an important endogenous regulator of vascular function. The aim of the present study was to investigate the control and consequences of CSE activity in endothelial cells under physiological and proatherogenic conditions.

Université de Fribourg

The role of glacier retreat for Swiss hydropower production

Schaefli, Bettina ; Manso, Pedro ; Fischerc, Mauro ; Huss, Matthias ; Farinotti, Daniel

In: Renewable Energy, 2019, vol. 132, p. 615–627

High elevation or high latitude hydropower production (HP) strongly relies on water resources that are influenced by glacier melt and are thus highly sensitive to climate warming. Despite of the wide-spread glacier retreat since the development of HP infrastructure in the 20th century, little quantitative information is available about the role of glacier mass loss for HP. In this paper, we...

Université de Fribourg

Nanoparticle administration method in cell culture alters particle-cell interaction

Moore, Thomas L. ; Urban, Dominic A. ; Rodriguez-Lorenzo, Laura ; Milosevic, Ana ; Crippa, Federica ; Spuch-Calvar, Miguel ; Balog, Sandor ; Rothen-Rutishauser, Barbara ; Lattuada, Marco ; Petri-Fink, Alke

In: Scientific Reports, 2019, vol. 9, no. 1, p. 900

As a highly interdisciplinary field, working with nanoparticles in a biomedical context requires a robust understanding of soft matter physics, colloidal behaviors, nano- characterization methods, biology, and bio-nano interactions. When reporting results, it can be easy to overlook simple, seemingly trivial experimental details. In this context, we set out to understand how in vitro...

Université de Fribourg

Time- and angle-resolved photoemission spectroscopy of solids in the extreme ultraviolet at 500 kHz repetition rate

Puppin, M. ; Deng, Y. ; Nicholson, C. W. ; Feldl, J. ; Schröter, N. B. M. ; Vita, H. ; Kirchmann, P. S. ; Monney, Claude ; Rettig, L. ; Wolf, M. ; Ernstorfer, R.

In: Review of Scientific Instruments, 2019, vol. 90, no. 2, p. 023104

Time- and angle-resolved photoemission spectroscopy (trARPES) employing a 500 kHz extreme-ultraviolet light source operating at 21.7 eV probe photon energy is reported. Based on a high-power ytterbium laser, optical parametric chirped pulse amplification, and ultraviolet-driven high-harmonic generation, the light source produces an isolated high-harmonic with 110 meV bandwidth and a flux of...

Université de Fribourg

Histoire et archéologie de la culture ludique dans le monde gréco-romain

Dasen, Véronique

In: Kentron. Revue pluridisciplinaire du monde antique, 2018, vol. 34, p. 23-50

L’histoire et l’archéologie de la culture ludique représentent un vaste champ de recherches pluridisciplinaire en partie inexploré. Un premier bilan des travaux en cours peut être dressé en soulevant les principales questions méthodologiques relatives aux questions d’identification des jeux et jouets.

Université de Fribourg

Pressesprache und Standardisierung : Engadin und Surselva im 20. Jahrhundert

Grünert, Matthias

In: Ladinia, 2003, vol. 27, p. 21-40

Der Beitrag befasst sich mit der Umsetzung schriftsprachlicher Normen in der rätoromanischen Presse zweier Regionen Graubündens, des Engadins und der Surselva, in zwei Zeitabschnitten, die durch Reformen geprägt sind. Zunächst werden Reformen und deren Umsetzung in den 1920-er und 1930-er Jahren dargestellt, als im Anschluss an die Diskussionen um den italienischen Einfluss im...