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Université de Fribourg

Dental anomaly in a middle Miocene fossil of the genus Spermophilinus (Rodentia, Sciuridae) from southern Germany

Prieto, Jérôme ; Rummel, Michael ; Peláez-Campomanes, Pablo ; Vasilyan, Davit

In: Fossil Imprint, 2020, vol. 76, no. 1, p. 174-180

The maxillary presented in this work has been excavated in the middle Miocene karst filling Petersbuch 136 (Germany, Bavaria) and shows the oldest evidence of dental anomaly in a sciurid. The aberrant morphology, probably hyperdontia or no replacement of roots of deciduous teeth, affects the area of the P3, a tooth that is generally not well documented in the Spermophilinus record.

Université de Fribourg

An ATP-dependent partner switch links flagellar C-ring assembly with gene expression

Blagotinsek, Vitan ; Schwan, Meike ; Steinchen, Wieland ; Mrusek, Devid ; Hook, John C. ; Rossmann, Florian ; Freibert, Sven A. ; Kratzat, Hanna ; Murat, Guillaume ; Kressler, Dieter ; Beckmann, Roland ; Beeby, Morgan ; Thormann, Kai M. ; Bange, Gert

In: Proceedings of the National Academy of Sciences, 2020, vol. 117, no. 34, p. 20826–20835

Bacterial flagella differ in their number and spatial arrangement. In many species, the MinD-type ATPase FlhG (also YlxH/FleN) is central to the numerical control of bacterial flagella, and its deletion in polarly flagellated bacteria typically leads to hyperflagellation. The molecular mechanism underlying this numerical control, however, remains enigmatic. Using the model species Shewanella...

Université de Fribourg

Notes on the cheek region of the Late Jurassic theropod dinosaur Allosaurus

Evers, Serjoscha W. ; Foth, Christian ; Rauhut, Oliver W.M.

In: PeerJ, 2020, vol. 8, p. e8493

Allosaurus, from the Late Jurassic of North America and Europe, is a model taxon for Jurassic basal tetanuran theropod dinosaurs. It has achieved an almost iconic status due to its early discovery in the late, 19th century, and due to the abundance of material from the Morrison Formation of the western U.S.A., making Allosaurus one of the best-known theropod taxa. Despite this, various...

Université de Fribourg

Assessment of the potential for in-plume sulphur dioxide gas-ash interactions to influence the respiratory toxicity of volcanic ash

Tomašek, Ines ; Damby, David E. ; Horwell, Claire J. ; Ayris, Paul M. ; Delmelle, Pierre ; Ottley, Christopher J. ; Cubillas, Pablo ; Casas, Ana S. ; Bisig, Christoph ; Petri-Fink, Alke ; Dingwell, Donald B. ; Clift, Martin J. D. ; Drasler, Barbara ; Rothen-Rutishauser, Barbara

In: Environmental Research, 2019, vol. 179, p. 108798

Volcanic plumes are complex environments composed of gases and ash particles, where chemical and physical processes occur at different temperature and compositional regimes. Commonly, soluble sulphate- and chloride-bearing salts are formed on ash as gases interact with ash surfaces. Exposure to respirable volcanic ash following an eruption is potentially a significant health concern. The...

Université de Fribourg

Directing single-molecule emission with dna origami-assembled optical antennas

Hübner, Kristina ; Pilo-Pais, Mauricio ; Selbach, Florian ; Liedl, Tim ; Tinnefeld, Philip ; Stefani, Fernando D. ; Acuna, Guillermo P.

In: Nano Letters, 2019, vol. 19, no. 9, p. 6629–6634

We demonstrate the capability of DNA self-assembled optical antennas to direct the emission of an individual fluorophore, which is free to rotate. DNA origami is used to fabricate optical antennas composed of two colloidal gold nanoparticles separated by a predefined gap and to place a single Cy5 fluorophore near the gap center. Although the fluorophore is able to rotate, its excitation and...

Università della Svizzera italiana

TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut

Romagnani, Andrea ; Vettore, Valentina ; Rezzonico-Jost, Tanja ; Hampe, Sarah ; Rottoli, Elsa ; Nadolni, Wiebke ; Perotti, Michela ; Meier, Melanie A. ; Hermanns, Constanze ; Geiger, Sheila ; Wennemuth, Gunther ; Recordati, Camilla ; Matsushita, Masayuki ; Muehlich, Susanne ; Proietti, Michele ; Chubanov, Vladimir ; Gudermann, Thomas ; Grassi, Fabio ; Zierler, Susanna

In: Nature communications, 2017, vol. 8, p. 1917

The melastatin-like transient-receptor-potential-7 protein (TRPM7), harbouring a cation channel and a serine/threonine kinase, has been implicated in thymopoiesis and cytokine expression. Here we show, by analysing TRPM7 kinase-dead mutant (Trpm7 R/R) mice, that the enzymatic activity of the receptor is not essential for thymopoiesis, but is required for CD103 transcription and gut-homing of ...