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Targeting the DNA damage response for patients with lymphoma : preclinical and clinical evidences

Carrassa, Laura ; Colombo, Ilaria ; Damia, Giovanna ; Bertoni, Francesco

In: Cancer treatment reviews, 2020, vol. 90, p. 11

The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be...

Personal or first-degree family breast cancer history: which has higher impact on tumor detection and tumor size in breast cancer

Schwab, Fabienne ; Kilic, Nerbil ; Huang, Dorothy ; Schmid, Seraina ; Vetter, Marcus ; Schötzau, Andreas ; Güth, Uwe

In: Archives of Gynecology and Obstetrics, 2015, vol. 291, no. 6, p. 1387-1394

Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups

Weller, Michael ; Weber, Ruthild ; Willscher, Edith ; Riehmer, Vera ; Hentschel, Bettina ; Kreuz, Markus ; Felsberg, Jörg ; Beyer, Ulrike ; Löffler-Wirth, Henry ; Kaulich, Kerstin ; Steinbach, Joachim ; Hartmann, Christian ; Gramatzki, Dorothee ; Schramm, Johannes ; Westphal, Manfred ; Schackert, Gabriele ; Simon, Matthias ; Martens, Tobias ; Boström, Jan ; Hagel, Christian ; Sabel, Michael ; Krex, Dietmar ; Tonn, Jörg ; Wick, Wolfgang ; Noell, Susan ; Schlegel, Uwe ; Radlwimmer, Bernhard ; Pietsch, Torsten ; Loeffler, Markus ; von Deimling, Andreas ; Binder, Hans ; Reifenberger, Guido

In: Acta Neuropathologica, 2015, vol. 129, no. 5, p. 679-693

High tumor budding stratifies breast cancer with metastatic properties

Salhia, Bodour ; Trippel, Mafalda ; Pfaltz, Katrin ; Cihoric, Nikola ; Grogg, André ; Lädrach, Claudia ; Zlobec, Inti ; Tapia, Coya

In: Breast Cancer Research and Treatment, 2015, vol. 150, no. 2, p. 363-371

Suppression of lung metastases by the CD26/DPP4 inhibitor Vildagliptin in mice

Jang, Jae-Hwi ; Baerts, Lesley ; Waumans, Yannick ; De Meester, Ingrid ; Yamada, Yoshito ; Limani, Perparim ; Gil-Bazo, Ignacio ; Weder, Walter ; Jungraithmayr, Wolfgang

In: Clinical & Experimental Metastasis, 2015, vol. 32, no. 7, p. 677-687

Health-related quality of life in young survivors of childhood cancer

Wengenroth, L. ; Gianinazzi, M. ; Rueegg, C. ; Lüer, S. ; Bergstraesser, E. ; Kuehni, C. ; Michel, G.

In: Quality of Life Research, 2015, vol. 24, no. 9, p. 2151-2161

Live Virus Vaccines in Transplantation: Friend or Foe?

Verolet, Charlotte ; Posfay-Barbe, Klara

In: Current Infectious Disease Reports, 2015, vol. 17, no. 4, p. 1-11

CD4+ T-Cell Reactivity to Orexin/Hypocretin in Patients With Narcolepsy Type 1

Ramberger, Melanie ; Högl, Birgit ; Stefani, Ambra ; Mitterling, Thomas ; Reindl, Markus ; Lutterotti, Andreas

In: SLEEP, 2016, vol. 40, no. 3, p. -

Structure and function analysis of an antibody recognizing all influenza A subtypes

Kallewaard, Nicole L. ; Corti, Davide ; Collins, Patrick J. ; Neu, Ursula ; McAuliffe, Josephine M. ; Benjamin, Ebony ; Wachter-Rosati, Leslie ; Palmer-Hill, Frances J. ; Yuan, Andy Q. ; Walker, Philip A. ; Vorlaender, Matthias K. ; Bianchi, Siro ; Guarino, Barbara ; De Marco, Anna ; Vanzetta, Fabrizia ; Agatic, Gloria ; Foglierini, Mathilde ; Pinna, Debora ; Fernandez-Rodriguez, Blanca ; Fruehwirth, Alexander ; Silacci, Chiara ; Ogrodowicz, Roksana W. ; Martin, Stephen R. ; Sallusto, Federica ; Suzich, JoAnn A. ; Lanzavecchia, Antonio ; Zhu, Qing ; Gamblin, Steven J. ; Skehel, John J.

In: Cell, 2016, vol. 166, no. 3, p. 596-608

Influenza virus remains a threat because of its ability to evade vaccine-induced immune responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a broad-spectrum human monoclonal antibody (mAb), MEDI8852, effectively reacting with all influenza A hemagglutinin (HA) subtypes. MEDI8852 uses the heavy-chain VH6-1 gene and has higher potency and breadth when...

Identification and structure of a multidonor class of head-directed influenza-neutralizing antibodies reveal the mechanism for its recurrent elicitation

Sao-Fong Cheung, Crystal ; Fruehwirth, Alexander ; Paparoditis, Philipp Carl Georg ; Shen, Chen-Hsiang ; Foglierini, Mathilde ; Joyce, M. Gordon ; Leung, Kwanyee ; Piccoli, Luca ; Rawi, Reda ; Silacci-Fregni, Chiara ; Tsybovsky, Yaroslav ; Verardi, Raffaello ; Wang, Lingshu ; Wang, Shuishu ; Yang, Eun Sung ; Zhang, Baoshan ; Zhang, Yi ; Chuang, Gwo-Yu ; Corti, Davide ; Mascola, John R. ; Shapiro, Lawrence ; Kwong, Peter D. ; Lanzavecchia, Antonio ; Zhou, Tongqing

In: Cell reports, 2020, vol. 32, no. 9, p. 12 p

Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize a multidonor antibody class (LPAF-a class) targeting the HA head. This class...