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FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P3 and phosphoinositide 3-kinase

Imeri, Faik ; Blanchard, Olivier ; Jenni, Aurelio ; Schwalm, Stephanie ; Wünsche, Christin ; Zivkovic, Aleksandra ; Stark, Holger ; Pfeilschifter, Josef ; Huwiler, Andrea

In: Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, vol. 388, no. 12, p. 1283-1292

Endothelial nitric oxide synthase in the microcirculation

Shu, Xiaohong ; Keller IV, T. ; Begandt, Daniela ; Butcher, Joshua ; Biwer, Lauren ; Keller, Alexander ; Columbus, Linda ; Isakson, Brant

In: Cellular and Molecular Life Sciences, 2015, vol. 72, no. 23, p. 4561-4575

Adaptive reorientation of endothelial collectives in response to strain

Bernardi, Laura ; Giampietro, Costanza ; Marina, Vita ; Genta, Martina ; Mazza, Edoardo ; Ferrari, Aldo

In: Integrative Biology, 2018, vol. 10, no. 9, p. 527-538

Hypoxia enhances endothelial intercellular adhesion molecule 1 protein level through upregulation of arginase type II and mitochondrial oxidative stress

Liang, Xiujie ; Arullampalam, Prakash ; Yang, Zhihong ; Ming, Xiu-Fen

In: Frontiers in Physiology, 2019, vol. 10, p. -

Hypoxia plays a crucial role in the pathogenesis of cardiovascular diseases. Mitochondrial enzyme arginase type II (Arg-II) is reported to lead to endothelial dysfunction and enhance the expression of endothelial inflammatory adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). In this study, we investigate the role of Arg-II in...

MAGI1 mediates eNOS activation and NO production in endothelial cells in response to fluid shear stress

Ghimire, Kedar ; Zaric, Jelena ; Alday-Parejo, Begoña ; Seebach, Jochen ; Bousquenaud, Mélanie ; Stalin, Jimmy ; Bieler, Grégory ; Schnittler, Hans-Joachim ; Rüegg, Curzio

In: Cells, 2019, vol. 8, no. 5, p. 388

Fluid shear stress stimulates endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production through multiple kinases, including protein kinase A (PKA), AMP-activated protein kinase (AMPK), AKT and Ca2+/calmodulin-dependent protein kinase II (CaMKII). Membrane-associated guanylate kinase (MAGUK) with inverted domain structure-1 (MAGI1) is an adaptor protein that...

Novel insights into the development and maintenance of the blood-brain barrier

Engelhardt, Britta ; Liebner, Stefan

In: Cell and Tissue Research, 2014, vol. 355, no. 3, p. 687-699

The inflammatory response of lymphatic endothelium

Aebischer, David ; Iolyeva, Maria ; Halin, Cornelia

In: Angiogenesis, 2014, vol. 17, no. 2, p. 383-393

The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions

Steiner, Esther ; Enzmann, Gaby ; Lyck, Ruth ; Lin, Shuo ; Rüegg, Markus ; Kröger, Stephan ; Engelhardt, Britta

In: Cell and Tissue Research, 2014, vol. 358, no. 2, p. 465-479

Lymphatic vessels: new targets for the treatment of inflammatory diseases

Dieterich, Lothar ; Seidel, Catharina ; Detmar, Michael

In: Angiogenesis, 2014, vol. 17, no. 2, p. 359-371

Evaluation of extracellular vesicle function during malaria infection

Andrea Hernández-Castañeda, María ; Mbagwu, Smart Ikechukwu ; Babatunde, Kehinde Adebayo ; Walch, Michael ; Filgueira, Luis ; Mantel, Pierre-Yves

In: JoVE (Journal of Visualized Experiments), 2018, no. 132, p. e57067

Malaria is a life-threatening disease caused by Plasmodium parasites, with P. falciparum being the most prevalent on the African continent and responsible for most malaria-related deaths globally. Several factors including parasite sequestration in tissues, vascular dysfunction, and inflammatory responses influence the evolution of the disease in malaria-infected people. P. falciparum-infected...