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Université de Fribourg

Ecdysone triggered PGRP‐LC expression controls Drosophila innate immunity

Rus, Florentina ; Flatt, Thomas ; Tong, Mei ; Aggarwal, Kamna ; Okuda, Kendi ; Kleino, Anni ; Yates, Elisabeth ; Tatar, Marc ; Silverman, Neal

In: The EMBO Journal, 2013, vol. 32, no. 11, p. 1626–1638

Throughout the animal kingdom, steroid hormones have been implicated in the defense against microbial infection, but how these systemic signals control immunity is unclear. Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP‐LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial...

Université de Fribourg

Reduced caterpillar damage can benefit plant bugs in Bt cotton

Eisenring, Michael ; Naranjo, Steven E. ; Bacher, Sven ; Abbott, Angelique ; Meissle, Michael ; Romeis, Jörg

In: Scientific Reports, 2019, vol. 9, no. 1, p. 2727

Bt cotton was genetically modified to produce insecticidal proteins targeting Lepidopteran pests and is therefore only minimally affected by caterpillar damage. This could lead to reduced levels of inherent, systemically inducible defensive compounds in Bt cotton which might benefit other important cotton herbivores such as plant bugs. We studied the effects of plant defense induction on the...

Université de Fribourg

H2S, a Bacterial Defense Mechanism against the Host Immune Response

Toliver-Kinsky, Tracy ; Cui, Weihua ; Törö, Gabor ; Lee, Seung-Jin ; Shatalin, Konstantin ; Nudler, Evgeny ; Szabo, Csaba

In: Infection and Immunity, 2019, vol. 87, no. 1, p. e00272-18

The biological mediator hydrogen sulfide (H2S) is produced by bacteria and has been shown to be cytoprotective against oxidative stress and to increase the sensitivity of various bacteria to a range of antibiotic drugs. Here we evaluated whether bacterial H2S provides resistance against the immune response, using two bacterial species that are common sources of nosocomial infections,...

Université de Fribourg

Bacillus subtilis PTA-271 counteracts Botryosphaeria dieback in grapevine, triggering immune responses and detoxification of fungal phytotoxins

Trotel-Aziz, Patricia ; Abou-Mansour, Eliane ; Courteaux, Barbara ; Rabenoelina, Fanja ; Clément, Christophe ; Fontaine, Florence ; Aziz, Aziz

In: Frontiers in Plant Science, 2019, vol. 10, p. -

Plant pathogens have evolved various strategies to enter hosts and cause diseases. Particularly Neofusicoccum parvum, a member of Botryosphaeria dieback consortium, can secrete the phytotoxins (-)-terremutin and (R)-mellein during grapevine colonization. The contribution of phytotoxins to Botryosphaeria dieback symptoms still remains unknown. Moreover, there are currently no efficient control...

Consortium of Swiss Academic Libraries

Toll-like receptors in domestic animals

Jungi, Thomas ; Farhat, Katja ; Burgener, Iwan ; Werling, Dirk

In: Cell and Tissue Research, 2011, vol. 343, no. 1, p. 107-120