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Université de Fribourg

The effect of maternal immunisation during pregnancy on infant vaccine responses

Zimmermann, Petra ; Perrett, Kirsten P. ; Messina, Nicole L. ; Donatha, Susan ; Ritz, Nicole ; Klis, Fiona R. M. van der ; Curtis, Nigel

In: EClinicalMedicine, 2019, vol. 13, p. 21–30

Immunisation during pregnancy to protect infants against tetanus, pertussis and influenza is recommended in many countries. However, maternal antibodies can interfere with infant vaccine responses. We investigated the effect of antenatal diphtheria-tetanus-acellular pertussis (dTpa) and trivalent inactivated influenza (TIV) immunisation on specific and heterologous antibody responses to...

Université de Fribourg

Antimicrobial effects of antipyretics

Zimmermann, Petra ; Curtis, Nigel

In: Antimicrobial Agents and Chemotherapy, 2017, vol. 61, no. 4, p. -

Antipyretics are some of the most commonly used drugs. Since they are often coadministered with antimicrobial therapy, it is important to understand the interactions between these two classes of drugs. Our review is the first to summarize the antimicrobial effects of antipyretic drugs and the underlying mechanisms involved. Antipyretics can inhibit virus replication, inhibit or promote...

Université de Fribourg

Effect of 3-mercaptopyruvate sulfurtransferase deficiency on the development of multiorgan failure, inflammation, and wound healing in mice subjected to burn injury

Ahmad, Akbar ; Druzhyna, Nadiya ; Szabo, Csaba

In: Journal of Burn Care & Research, 2019, vol. 40, no. 2, p. 148–156

The gaseous transmitter hydrogen sulfide (H2S) has been implicated in various forms of critical illness. Here, we have compared the outcome of scald burn injury in wild- type mice and in mice deficient in 3-mercaptopyruvate sulfurtransferase (3-MST), a mammalian H2S-generating enzyme. Outcome variables included indices of organ injury, clinical chemistry parameters, and plasma levels of...

Université de Fribourg

Biological sex influences antibody responses to routine vaccinations in the first year of life

Zimmermann, Petra ; Perrett, Kirsten P. ; Ritz,  Nicole ; Flanagan, Katie L. ; Robins-Browne, Roy ; Klis, Fiona R. M. van der ; Curtis, Nigel ; the MIS BAIR group

In: Acta Paediatrica, 2019, p. -

Aim We investigated the effect of early-life factors, namely sex, delivery mode, feeding method and antibiotic exposure, on antibody responses to routine vaccinations administered during the first year of life. Methods One and seven months after the primary course of routine vaccines and 1 month after routine vaccines at 12 months of age, antibodies against 26 vaccine antigens were measured...

Università della Svizzera italiana

The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer

Yasinska, Inna M. ; Sakhnevych, Svetlana S. ; Pavlova, Ludmila ; Hansen Selnø, Anette Teo ; Teuscher Abeleira, Ana Maria ; Benlaouer, Ouafa ; Gonçalves Silva, Isabel ; Mosimann, Marianne ; Varani, Luca ; Bardelli, Marco ; Hussain, Rohanah ; Siligardi, Giuliano ; Cholewa, Dietmar ; Berger, Steffen M. ; Gibbs, Bernhard F. ; Ushkaryov, Yuri A. ; Fasler-Kan, Elizaveta ; Klenova, Elena ; Sumbayev, Vadim V.

In: Frontiers in immunology, 2019, vol. 10, p. 1594

Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the disease. We have recently reported that the immune receptor Tim-3 and its natural ligand galectin-9 are involved in the immune escape of human acute myeloid leukemia (AML) cells. These cells use the neuronal receptor latrophilin 1...

Université de Fribourg

Swiss paediatrician survey on complementary medicine

Huber, Benedikt M. ; von Schoen-Angerer, Tido ; Hasselmann, Oswald ; Wildhaber, Johannes ; Wolf, Ursula

In: Swiss Medical Weekly, 2019, p. -

In Switzerland, complementary medicine (CM) is officially recognised within the healthcare system and mainly practised in an integrative manner, in conjunction with conventional medicine. As in other countries, there is high demand for and use of CM with children. However, there has so far been no research into the attitude towards, training in and offer of CM among paediatricians in...

Université de Fribourg

Non-typhoidal Salmonella blood stream infection in Kuwait: Clinical and microbiological characteristics

Albert, M. John ; Bulach, Dieter ; Alfouzan, Wadha ; Izumiya, Hidemasa ; Carter, Glen ; Alobaid, Khaled ; Alatar, Fatemah ; Sheikh, Abdul Rashid ; Poirel, Laurent

In: PLOS Neglected Tropical Diseases, 2019, vol. 13, no. 4, p. e0007293

Salmonella organisms are classified into typhoidal Salmonella (causing enteric fever) and non-typhoidal Salmonella (NTS) (causing infections other than enteric fever). Apart from causing other infections, NTS causes blood-stream infection (bacteremia and septicemia). NTS blood stream infection (NTS-BI) is considered to be an emerging and neglected tropical disease in Africa. It causes a very...