Affiner les résultats

Synthesis and properties of poly(norbornene)s with lateral aramid groups

Kong, Phally ; Drechsler, Susanne ; Balog, Sandor ; Schrettl, Stephen ; Weder, Christoph ; Kilbinger, Andreas F. M.

In: Polymer Chemistry, 2019, vol. 10, no. 16, p. 2057–2063

This paper deals with the synthesis and investigation of comb-like poly(norbornene)s carrying lateral rod-like aramid groups. Two types of norbornene-based monomers were synthesized and copolymerized with a norbornene carrying an aliphatic side chain using ring opening metathesis polymerization (ROMP). The new monomers contain aramid derivatives that display different types of non-covalent...

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity

Bardelli, Marco ; Frontzek, Karl ; Simonelli, Luca ; Hornemann, Simone ; Pedotti, Mattia ; Mazzola, Federica ; Carta, Manfredi ; Eckhardt, Valeria ; D’Antuono, Rocco ; Virgilio, Tommaso ; González, Santiago F. ; Aguzzi, Adriano ; Varani, Luca

In: Plos pathogens, 2018, vol. 14, no. 10, p. e1007335

Antibodies to the prion protein, PrP, represent a promising therapeutic approach against prion diseases but the neurotoxicity of certain anti-PrP antibodies has caused concern. Here we describe scPOM-bi, a bispecific antibody designed to function as a molecular prion tweezer. scPOM-bi combines the complementarity-determining regions of the neurotoxic antibody POM1 and the neuroprotective...

Aggregation Stability of a Monoclonal Antibody During Downstream Processing

Arosio, Paolo ; Barolo, Giuliano ; Müller-Späth, Thomas ; Wu, Hua ; Morbidelli, Massimo

In: Pharmaceutical Research, 2011, vol. 28, no. 8, p. 1884-1894

Aggregation Mechanism of an IgG2 and two IgG1 Monoclonal Antibodies at low pH: From Oligomers to Larger Aggregates

Arosio, Paolo ; Rima, Simonetta ; Morbidelli, Massimo

In: Pharmaceutical Research, 2013, vol. 30, no. 3, p. 641-654

A Computer-Glimpse of the Origin of Life

Kuhn, Christoph

In: Journal of Biological Physics, 2005, vol. 31, no. 3-4, p. 571-585

Biochemical characterization of Helicobacter pylori α-1,4 fucosyltransferase: metal ion requirement, donor substrate specificity and organic solvent stability

Rabbani, Said ; Corona, Francesco ; Ernst, Beat

In: BioMetals, 2009, vol. 22, no. 6, p. 1011-1017

Tracking of fluorescently labeled polymer particles reveals surface effects during shear-controlled aggregation

Caimi, Stefano ; Cingolani, Alberto ; Jaquet, Baptiste ; Siggel, Marc ; Lattuada, Marco ; Morbidelli, Massimo

In: Langmuir, 2017, vol. 33, no. 49, p. 14038–14044

Surface chemistry is believed to be the key parameter affecting the aggregation and breakage of colloidal suspensions when subjected to shear. To date, only a few works dealt with the understanding of the role of the physical and chemical properties of the particles’ surface upon aggregation under shear. Previous studies suggested that surface modifications strongly affect polymer...

Transfer of engineered biophysical properties between different antibody formats and expression systems

Schaefer, Jonas V. ; Plückthun, Andreas

In: Protein Engineering, Design & Selection, 2012, vol. 25, no. 10, p. 485-506

Charging and Aggregation of Positively Charged Colloidal Latex Particles in Presence of Multivalent Polycarboxylate Anions

Sadeghpour, Amin ; Szilágyi, István ; Borkovec, Michal

In: Zeitschrift für Physikalische Chemie, 2012, vol. 226, no. 7-8, p. 597-612

Toward large tubular helices based on the polymerization of tri(benzamide)s

Schulze, Maren ; Kilbinger, Andreas F. M.

In: Journal of Polymer Science Part A: Polymer Chemistry, 2016, p. -

Herein we present the synthesis and polycondensation of mono- and di-N-protected, bis-substituted tri(benzamide)s with the aim to create large, tubular helices. We synthesized 2,4-dimethoxy and 2,5-bis-TEGylated aminobenzoic acid derivatives as bent and linear monomers and introduced p-methoxybenzyl (PMB) amide protecting groups to the oligobenzamide backbone. An iterative coupling strategy...