In: Toxicological Sciences, 2018, vol. 162, no. 2, p. 702-712
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In: Scientific Reports, 2020, vol. 10, no. 1, p. 11551
Zebrafish can regenerate their damaged hearts throughout their lifespan. It is, however, unknown, whether regeneration remains effective when challenged with successive cycles of cardiac damage in the same animals. Here, we assessed ventricular restoration after two, three and six cryoinjuries interspaced by recovery periods. Using transgenic cell-lineage tracing analysis, we demonstrated...
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In: Current Opinion in Physiology, 2020, vol. 14, p. 21–26
Among adult vertebrates, the zebrafish presents the rather exceptional capacity to efficiently regenerate its heart after injury. This bony fish has thus become a leading genetic model organism to elucidate the natural mechanisms of successful cardiac restoration. Given its potential biomedical significance, parallel analyses between zebrafish and mammals are aiming at the identification of...
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In: Frontiers in Molecular Neuroscience, 2019, vol. 12, p. -
Aquatic vertebrates possess diverse types of sensory cells in their skin to detect stimuli in the water. In the adult zebrafish, a common model organism, the presence of such cells in fins has only rarely been studied. Here, we identified scattered serotonin (5-HT)-positive cells in the epidermis of the caudal fin. These cells were distinct from keratinocytes as revealed by their low...
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In: Wound Repair and Regeneration, 2019, p. wrr.12719
The zebrafish is a vertebrate organism capable of regenerating many of its organs. Notably, it can undergo epimorphic regeneration of its fins after amputation. This process occurs through the formation of a wound epithelium and the dedifferentiation of mesenchymal and bone‐forming cells, which form a proliferative blastema. Here, we report that the entry into the regenerative process...
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In: npj Regenerative Medicine, 2019, vol. 4, no. 1, p. 2
Unlike mammals, adult zebrafish can regenerate their hearts after injury via proliferation of cardiomyocytes. The cell-cycle entry of zebrafish cardiac cells can also be stimulated through preconditioning by thoracotomy, a chest incision without myocardial damage. To identify effector genes of heart preconditioning, we performed transcriptome analysis of ventricles from thoracotomized...
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In: Clinical Oral Investigations, 2014, vol. 18, no. 2, p. 443-451
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In: Cellular and Molecular Life Sciences, 2014, vol. 71, no. 12, p. 2241-2251
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In: Marine Organisms as Model Systems in Biology and Medicine, 2018, p. 337–355
The colonial marine invertebrate Botrylloides leachii belongs to the Tunicata subphylum, the closest invertebrate relatives to the vertebrate group and the only known class of chordates that can undergo whole-body regeneration (WBR). This dramatic developmental process allows a minute isolated fragment of B. leachii’s vascular system, or a colony excised of all adults, to restore a...
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In: The Journal of Membrane Biology, 2003, vol. 193, no. 2, p. 67-78
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