In: Cancer treatment reviews, 2020, vol. 90, p. 11
The DNA damage response (DDR) is a well-coordinated cellular network activated by DNA damage. The unravelling of the key players in DDR, their specific inactivation in different tumor types and the synthesis of specific chemical inhibitors of DDR represent a new hot topic in cancer therapy. In this article, we will review the importance of DDR in lymphoma development and how this can be...
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In: Journal of ethnicity in substance abuse, 2021, p. 1-19
Aims: To examine psychometric properties of the Daily Drinking Questionnaire (DDQ) in a Mediterranean “wet” drinking culture. Methods: Three studies were conducted using random samples drawn from a representative sample of Italian young adults (N¼5,955; females ¼ 62%; mean age ¼ 27): Study 1 explored the factorial structure of weekly alcohol consumption; in Study 2 multi-group...
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In: Nutrients, 2021, vol. 13, no. 6, p. 11
Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant...
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In: Current Treatment Options in Oncology, 2015, vol. 16, no. 9, p. 1-13
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In: Alcohol and Alcoholism, 2016, vol. 51, no. 5, p. 567-575
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In: European Journal of Nutrition, 2015, vol. 54, no. 1, p. 139-148
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In: Cancers, 2020, vol. 12, no. 10, p. 23 p
Triple-negative breast cancer (TNBC) is a heterogeneous disease that lacks effective therapeutic options. In this study, we profile eighteen TNBC cell lines for their sensitivity to the anti-proliferative action of all-trans retinoic acid (ATRA). The only three cell lines (HCC-1599, MB- 157 and MDA-MB-157) endowed with ATRA-sensitivity are characterized by genetic aberrations of the NOTCH1-gene,...
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In: Cell reports, 2019, vol. 26, no. 9, p. 2307-2315.e5
The role of natural killer (NK) cells in the immune response against vaccines is not fully understood. Here, we examine the function of infiltrated NK cells in the initiation of the inflammatory response triggered by inactivated influenza virus vaccine in the draining lymph node (LN). We observed that, following vaccination, NK cells are recruited to the interfollicular and medullary areas of...
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In: PLoS pathogens, 2015, vol. 11, no. 10, p. e1005164
Candida spp. can cause severe and chronic mucocutaneous and systemic infections in immunocompromised individuals. Protection from mucocutaneous candidiasis depends on T helper cells, in particular those secreting IL-17. The events regulating T cell activation and differentiation toward effector fates in response to fungal invasion in different tissues are poorly understood. Here we generated...
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In: Cancer Causes & Control, 2014, vol. 25, no. 4, p. 473-477
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