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Université de Fribourg

Practice-induced functional plasticity in inhibitory control interacts with aging

Hartmann, Lea ; Wachtl, Laura ; Lucia, Marzia de ; Spierer, Lucas

In: Brain and Cognition, 2019, vol. 132, p. 22–32

Inhibitory control deficits represent a key aspect of the cognitive declines associated with aging. Practicing inhibitory control has thus been advanced as a potential approach to compensate for age-induced neurocognitive impairments. Yet, the functional brain changes associated with practicing inhibitory control tasks in older adults and whether they differ from those observed in young...

Université de Fribourg

Corticotectal projections from the premotor or primary motor cortex after cortical lesion or parkinsonian symptoms in adult macaque monkeys: a pilot tracing study

Fregosi, Michela ; Contestabile, Alessandro ; Badoud, Simon ; Borgognon, Simon ; Cottet, Jérôme ; Brunet, Jean-François ; Bloch, Jocelyne ; Schwab, Martin E. ; Rouiller, Eric M.

In: Frontiers in Neuroanatomy, 2019, vol. 13, p. -

The corticotectal projections, together with the corticobulbar (corticoreticular) projections, work in parallel with the corticospinal tract (CST) to influence motoneurons in the spinal cord both directly and indirectly via the brainstem descending pathways. The tectospinal tract (TST) originates in the deep layers of the superior colliculus. In the present study, we analyzed the...

Università della Svizzera italiana

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

Belaunzaran, Osiris Marroquin ; Cordero, Maria Isabel ; Setola, Veronica ; Bianchi, Siro ; Galli, Carmela ; Bouche, Nicolas ; Mlynarik, Vladimir ; Gruetter, Rolf ; Sandi, Carmen ; Bensadoun, Jean-Charles ; Molinari, Maurizio ; Aebischer, Patrick

In: Plos one, 2011, vol. 6, no. 4, p. e18268

Background: Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinetics and tissue accessibility are the current principal disadvantages for broadening their use in clinic. Methodology and Principal Findings: We report a novel method for the long-term ...

Accès public à partir du 1 oct. 2019
Consortium of Swiss Academic Libraries

The chicken chorioallantoic membrane model in biology, medicine and bioengineering

Nowak-Sliwinska, Patrycja ; Segura, Tatiana ; Iruela-Arispe, M.

In: Angiogenesis, 2014, vol. 17, no. 4, p. 779-804

Accès public à partir du 1 nov. 2019
Consortium of Swiss Academic Libraries

A novel animal model for external anal sphincter insufficiency

Brügger, Lukas ; Inglin, Roman ; Candinas, Daniel ; Sulser, Tullio ; Eberli, Daniel

In: International Journal of Colorectal Disease, 2014, vol. 29, no. 11, p. 1385-1392