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Université de Fribourg

Antimicrobial Resistance in Escherichia coli

Poirel, Laurent ; Madec, Jean-Yves ; Lupo, Agnese ; Schink, Anne-Kathrin ; Kieffer, Nicolas ; Nordmann, Patrice ; Schwarz, Stefan

In: Microbiology Spectrum, 2018, vol. 6, no. 4, p. -

Multidrug resistance in Escherichia coli has become a worrying issue that is increasingly observed in human but also in veterinary medicine worldwide. E. coli is intrinsically susceptible to almost all clinically relevant antimicrobial agents, but this bacterial species has a great capacity to accumulate resistance genes, mostly through horizontal gene transfer. The most problematic...

Université de Fribourg

T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field

Sanz‑Ortega, Laura ; Rojas, José M. ; Marcos, Ana ; Portilla, Yadileiny ; Stein, Jens V. ; Barber, Domingo F.

In: Journal of Nanobiotechnology, 2019, vol. 17, no. 1, p. 14

T lymphocytes are highly dynamic elements of the immune system with a tightly regulated migration. T cell-based transfer therapies are promising therapeutic approaches which in vivo efficacy is often limited by the small proportion of administered cells that reaches the region of interest. Manipulating T cell localisation to improve specific targeting will increase the effectiveness of these...

Université de Fribourg

Surviving in the BRICS: the struggle of South African business in coping with new partners and investors

Wenzel, Nadine ; Freund, Bill ; Graefe, Olivier

In: International Review of Applied Economics, 2019, vol. 33, no. 1, p. 51–70

The purpose of this paper is to improve our understanding of how South African economic actors react to the gradual entry of non-South African BRICS firms in their established business areas. Throughout the twentieth century, South Africa’s trade and investment activities were conducted overwhelmingly with Western countries. However, the end of apartheid coincided with significant shifts as...

Université de Fribourg

Nanoparticle administration method in cell culture alters particle-cell interaction

Moore, Thomas L. ; Urban, Dominic A. ; Rodriguez-Lorenzo, Laura ; Milosevic, Ana ; Crippa, Federica ; Spuch-Calvar, Miguel ; Balog, Sandor ; Rothen-Rutishauser, Barbara ; Lattuada, Marco ; Petri-Fink, Alke

In: Scientific Reports, 2019, vol. 9, no. 1, p. 900

As a highly interdisciplinary field, working with nanoparticles in a biomedical context requires a robust understanding of soft matter physics, colloidal behaviors, nano- characterization methods, biology, and bio-nano interactions. When reporting results, it can be easy to overlook simple, seemingly trivial experimental details. In this context, we set out to understand how in vitro...

Université de Fribourg

Time- and angle-resolved photoemission spectroscopy of solids in the extreme ultraviolet at 500 kHz repetition rate

Puppin, M. ; Deng, Y. ; Nicholson, C. W. ; Feldl, J. ; Schröter, N. B. M. ; Vita, H. ; Kirchmann, P. S. ; Monney, Claude ; Rettig, L. ; Wolf, M. ; Ernstorfer, R.

In: Review of Scientific Instruments, 2019, vol. 90, no. 2, p. 023104

Time- and angle-resolved photoemission spectroscopy (trARPES) employing a 500 kHz extreme-ultraviolet light source operating at 21.7 eV probe photon energy is reported. Based on a high-power ytterbium laser, optical parametric chirped pulse amplification, and ultraviolet-driven high-harmonic generation, the light source produces an isolated high-harmonic with 110 meV bandwidth and a flux of...

Université de Fribourg

Histoire et archéologie de la culture ludique dans le monde gréco-romain

Dasen, Véronique

In: Kentron. Revue pluridisciplinaire du monde antique, 2018, vol. 34, p. 23-50

L’histoire et l’archéologie de la culture ludique représentent un vaste champ de recherches pluridisciplinaire en partie inexploré. Un premier bilan des travaux en cours peut être dressé en soulevant les principales questions méthodologiques relatives aux questions d’identification des jeux et jouets.

Université de Fribourg

Pressesprache und Standardisierung : Engadin und Surselva im 20. Jahrhundert

Grünert, Matthias

In: Ladinia, 2003, vol. 27, p. 21-40

Der Beitrag befasst sich mit der Umsetzung schriftsprachlicher Normen in der rätoromanischen Presse zweier Regionen Graubündens, des Engadins und der Surselva, in zwei Zeitabschnitten, die durch Reformen geprägt sind. Zunächst werden Reformen und deren Umsetzung in den 1920-er und 1930-er Jahren dargestellt, als im Anschluss an die Diskussionen um den italienischen Einfluss im...