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Université de Fribourg

A twist in the ABC : regulation of ABC transporter trafficking and transport by FK506‐binding proteins

Geisler, Markus ; Hegedűs, Tamás

In: FEBS Letters, 2020, vol. 594, no. 23, p. 3986-4000

Post-transcriptional regulation of ATP-binding cassette (ABC) proteins has been so far shown to encompass protein phosphorylation, maturation, and ubiquitination. Yet, recent accumulating evidence implicates FK506-binding proteins (FKBPs), a type of peptidylprolyl cis–trans isomerase (PPIase) proteins, in ABC transporter regulation. In this perspective article, we summarize current knowledge on...

Université de Fribourg

Auxin-transporting ABC transporters are defined by a conserved D/E-P motif regulated by a prolylisomerase

Hao, Pengchao ; Xia, Jian ; Liu, Jie ; Donato, Martin Di ; Pakula, Konrad ; Bailly, Aurélien ; Jasinski, Michal ; Geisler, Markus

In: Journal of Biological Chemistry, 2020, vol. 295, no. 37, p. 13094–13105

The plant hormone auxin must be transported throughout plants in a cell-to-cell manner to affect its various physiological functions. ABCB transporters are critical for this polar auxin distribution, but the regulatory mechanisms controlling their function is not fully understood. The auxin transport activity of ABCB1 was suggested to be regulated by a physical interaction with FKBP42/Twisted...

Université de Fribourg

A substrate of the ABC transporter PEN3 stimulates bacterial flagellin (flg22)-induced callose deposition in Arabidopsis thaliana

Matern, Andreas ; Böttcher, Christoph ; Eschen-Lippold, Lennart ; Westermann, Bernhard ; Smolka, Ulrike ; Döll, Stefanie ; Trempel, Fabian ; Aryal, Bibek ; Scheel, Dierk ; Geisler, Markus ; Rosahl, Sabine

In: Journal of Biological Chemistry, 2019, vol. 294, no. 17, p. 6857–6870

Nonhost resistance of Arabidopsis thaliana against Phytophthora infestans, a filamentous eukaryotic microbe and the causal agent of potato late blight, is based on a multilayered defense system. Arabidopsis thaliana controls pathogen entry through the penetration-resistance genes PEN2 and PEN3, encoding an atypical myrosinase and an ABC transporter, respectively, required for synthesis and...