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Université de Fribourg

Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome

Pecze, Laszlo ; Randi, Elisa B. ; Szabo, Csaba

In: Molecular Medicine, 2020, vol. 26, no. 1, p. 102

Clinical observations and preclinical studies both suggest that Down syndrome (DS) may be associated with significant metabolic and bioenergetic alterations. However, the relevant scientific literature has not yet been systematically reviewed. The aim of the current study was to conduct a meta-analysis of metabolites involved in bioenergetics pathways in DS to conclusively determine the...

Université de Fribourg

A biologically-inspired model to predict perceived visual speed as a function of the stimulated portion of the visual field

Solari, Fabio ; Caramenti, Martina ; Chessa, Manuela ; Pretto, Paolo ; Bülthoff, Heinrich H. ; Bresciani, Jean-Pierre

In: Frontiers in Neural Circuits, 2019, vol. 13, p. -

Spatial orientation relies on a representation of the position and orientation of the body relative to the surrounding environment. When navigating in the environment, this representation must be constantly updated taking into account the direction, speed, and amplitude of body motion. Visual information plays an important role in this updating process, notably via optical flow. Here, we...

Université de Fribourg

Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy

Hasler, Gregor ; Buchmann, Andreas ; Haynes, Melanie ; Müller, Sabrina Theresia ; Ghisleni, Carmen ; Brechbühl, Sarela ; Tuura, Ruth

In: Translational Psychiatry, 2019, vol. 9, no. 1, p. 170

There is growing evidence for GABA and glutamate–glutamine dysfunction in the pathogenesis of mood and anxiety disorders. It is important to study this pathology in the early phases of the illness in order to develop new approaches to secondary prevention. New magnetic resonance spectroscopy (MRS) measures allow determining glutamine, the principal metabolite of synaptic glutamate that is...