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Université de Neuchâtel

Stochastic simulation of channelized sedimentary bodies using a constrained L-system

Rongier, G ; Collon, P ; Renard, Philippe

In: Computers & Geosciences, 2017, vol. 105, p. 158-168

Simulating realistic sedimentary bodies while conditioning all the available data is a major topic of research. We present a new method to simulate the channel morphologies resulting from the deposition processes. It relies on a formal grammar system, the Lindenmayer system, or L-system. The L-system puts together channel segments based on user-defined rules and parameters. The succession of...

Università della Svizzera italiana

Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma

Jacquelot, Nicolas ; Enot, David P. ; Flament, Caroline ; Vimond, Nadège ; Blattner, Carolin ; Pitt, Jonathan M. ; Yamazaki, Takahiro ; Roberti, María Paula ; Daillère, Romain ; Vétizou, Marie ; Poirier-Colame, Vichnou ; Semeraro, Michaëla ; Caignard, Anne ; Slingluff Jr., Craig L. ; Sallusto, Federica ; Rusakiewicz, Sylvie ; Weide, Benjamin ; Marabelle, Aurélien ; Kohrt, Holbrook ; Dalle, Stéphane ; Cavalcanti, Andréa ; Kroemer, Guido ; Di Giacomo, Anna Maria ; Maio, Michele ; Wong, Phillip ; Yuan, Jianda ; Wolchok, Jedd ; Umansky, Viktor ; Eggermont, Alexander ; Zitvogel, Laurence

In: The journal of clinical investigation, 2016, vol. 126, no. 3, p. 921-937

Melanoma prognosis is dictated by tumor-infiltrating lymphocytes, the migratory and functional behavior of which is guided by chemokine or cytokine gradients. Here, we retrospectively analyzed the expression patterns of 9 homing receptors (CCR/CXCR) in naive and memory CD4+ and CD8+ T lymphocytes in 57 patients with metastatic melanoma (MMel) with various sites of metastases to evaluate...

Université de Fribourg

Permafrost is warming at a global scale

Biskaborn, Boris K. ; Smith, Sharon L. ; Noetzli, Jeannette ; Matthes, Heidrun ; Vieira, Gonçalo ; Streletskiy, Dmitry A. ; Schoeneich, Philippe ; Romanovsky, Vladimir E. ; Lewkowicz, Antoni G. ; Abramov, Andrey ; Allard, Michel ; Boike, Julia ; Cable, William L. ; Christiansen, Hanne H. ; Delaloye, Reynald ; Diekmann, Bernhard ; Drozdov, Dmitry ; Etzelmüller, Bernd ; Grosse, Guido ; Guglielmin, Mauro ; Ingeman-Nielsen, Thomas ; Isaksen, Ketil ; Ishikawa, Mamoru ; Johansson, Margareta ; Johannsson, Halldor ; Joo, Anseok ; Kaverin, Dmitry ; Kholodov, Alexander ; Konstantinov, Pavel ; Kröger, Tim ; Lambiel, Christophe ; Lanckman, Jean-Pierre ; Luo, Dongliang ; Malkova, Galina ; Meiklejohn, Ian ; Moskalenko, Natalia ; Oliva, Marc ; Phillips, Marcia ; Ramos, Miguel ; Sannel, A. Britta K. ; Sergeev, Dmitrii ; Seybold, Cathy ; Skryabin, Pavel ; Vasiliev, Alexander ; Wu, Qingbai ; Yoshikawa, Kenji ; Zheleznyak, Mikhail ; Lantuit, Hugues

In: Nature Communications, 2019, vol. 10, no. 1, p. 264

Permafrost warming has the potential to amplify global climate change, because when frozen sediments thaw it unlocks soil organic carbon. Yet to date, no globally consistent assessment of permafrost temperature change has been compiled. Here we use a global data set of permafrost temperature time series from the Global Terrestrial Network for Permafrost to evaluate temperature change across...

Université de Fribourg

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Carmona-Gutierrez, Didac ; Zimmermann, Andreas ; Kainz, Katharina ; Pietrocola, Federico ; Chen, Guo ; Maglioni, Silvia ; Schiavi, Alfonso ; Nah, Jihoon ; Mertel, Sara ; Beuschel, Christine B. ; Castoldi, Francesca ; Sica, Valentina ; Trausinger, Gert ; Raml, Reingard ; Sommer, Cornelia ; Schroeder, Sabrina ; Hofer, Sebastian J. ; Bauer, Maria A. ; Pendl, Tobias ; Tadic, Jelena ; Dammbrueck, Christopher ; Hu, Zehan ; Ruckenstuhl, Christoph ; Eisenberg, Tobias ; Durand, Sylvere ; Bossut, Noélie ; Aprahamian, Fanny ; Abdellatif, Mahmoud ; Sedej, Simon ; Enot, David P. ; Wolinski, Heimo ; Dengjel, Jörn ; Kepp, Oliver ; Magnes, Christoph ; Sinner, Frank ; Pieber, Thomas R. ; Sadoshima, Junichi ; Ventura, Natascia ; Sigrist, Stephan J. ; Kroemer, Guido ; Madeo, Frank

In: Nature Communications, 2019, vol. 10, no. 1, p. 651

Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4′- dimethoxychalcone (DMC) as a natural compound with anti-ageing...

Université de Neuchâtel

Human impact erodes chimpanzee behavioral diversity

Kühl, Hjalmar S ; Boesch, Christophe ; Kulik, Lars ; Haas, Fabien ; Arandjelovic, Mimi ; Dieguez, Paula ; Bocksberger, Gaëlle ; McElreath, Mary Brooke ; Agbor, Anthony ; Angedakin, Samuel ; Ayimisin, Emmanuel Ayuk ; Bailey, Emma ; Barubiyo, Donatienne ; Bessone, Mattia ; Brazzola, Gregory ; Chancellor, Rebecca ; Cohen, Heather ; Coupland, Charlotte ; Danquah, Emmanuel ; Deschner, Tobias ; Dowd, Dervla ; Dunn, Andrew ; Egbe, Villard Ebot ; Eshuis, Henk ; Goedmakers, Annemarie ; Granjon, Anne-Céline ; Head, Josephine ; Hedwig, Daniela ; Hermans, Veerle ; Imong, Inaoyom ; Jeffery, Kathryn J ; Jones, Sorrel ; Junker, Jessica ; Kadam, Parag ; Kambere, Mbangi ; Kambi, Mohamed ; Kienast, Ivonne ; Kujirakwinja, Deo ; Langergraber, Kevin E ; Lapuente, Juan ; Larson, Bradley ; Lee, Kevin ; Leinert, Vera ; Llana, Manuel ; Maretti, Giovanna ; Marrocoli, Sergio ; Martin, Rumen ; Mbi, Tanyi Julius ; Meier, Amelia C ; Morgan, Bethan ; Morgan, David ; Mulindahabi, Felix ; Murai, Mizuki ; Neil, Emily ; Niyigaba, Protais ; Ormsby, Lucy Jayne ; Orume, Robinson ; Pacheco, Liliana ; Piel, Alex ; Preece, Jodie ; Regnaut, Sebastien ; Rundus, Aaron ; Sanz, Crickette ; Schijndel, Joost van ; Sommer, Volker ; Stewart, Fiona ; Tagg, Nikki ; Vendras, Elleni ; Vergnes, Virginie ; Welsh, Adam ; Wessling, Erin G ; Willie, Jacob ; Wittig, Roman M ; Ginath Yuh, Yisa ; Yurkiw, Kyle ; Zuberbühler, Klaus ; Kalan, Ammie K

In: Science, 2019, vol. 363, no. 6434, p. 1453-1455

Chimpanzees possess a large number of behavioral and cultural traits among nonhuman species. The “disturbance hypothesis” predicts that human impact depletes resources and disrupts social learning processes necessary for behavioral and cultural transmission. We used a dataset of 144 chimpanzee communities, with information on 31 behaviors, to show that chimpanzees inhabiting areas with high...