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Università della Svizzera italiana

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

Genini, Davide ; Brambilla, Lara ; Laurini, Erik ; Merulla, Jessica ; Civenni, Gianluca ; Pandit, Shusil ; D'Antuono, Rocco ; Perez, Laurent ; Levy, David E. ; Pricl, Sabrina ; Carbone, Giuseppina M. ; Catapano, Carlo V.

In: Proceedings of the national academy of sciences of the United States of America, 2017, vol. 114, no. 25, p. E4924-E4933

In addition to its canonical role in nuclear transcription, signal transducer and activator of transcription 3 (STAT3) is emerging as an important regulator of mitochondrial function. Here, we demonstrate that a novel inhibitor that binds with high affinity to the STAT3 SH2 domain triggers a complex cascade of events initiated by interference with mitochondrial STAT3 (mSTAT3). The...

Consortium of Swiss Academic Libraries

The mTOR Pathway in Breast Cancer

Hynes, Nancy ; Boulay, Anne

In: Journal of Mammary Gland Biology and Neoplasia, 2006, vol. 11, no. 1, p. 53-61

Consortium of Swiss Academic Libraries

Contribution of hypoxia to Alzheimer's disease: is HIF-1α a mediator of neurodegeneration?

Ogunshola, O. ; Antoniou, X.

In: Cellular and Molecular Life Sciences, 2009, vol. 66, no. 22, p. 3555-3563

Consortium of Swiss Academic Libraries

Cell cycle control and cancer

Wagner, Hans

In: The Indian Journal of Pediatrics, 1998, vol. 65, no. 6, p. 805-814

Consortium of Swiss Academic Libraries

Myc and Mammary Cancer: Myc is a Downstream Effector of the ErbB2 Receptor Tyrosine Kinase

Hynes, Nancy ; Lane, Heidi

In: Journal of Mammary Gland Biology and Neoplasia, 2001, vol. 6, no. 1, p. 141-150

Consortium of Swiss Academic Libraries

The CDK inhibitors in cancer research and therapy

Cicenas, Jonas ; Valius, Mindaugas

In: Journal of Cancer Research and Clinical Oncology, 2011, vol. 137, no. 10, p. 1409-1418

Consortium of Swiss Academic Libraries

Cell cycle regulation by the B-Myb transcription factor

Joaquin, M. ; Watson, R.

In: Cellular and Molecular Life Sciences CMLS, 2003, vol. 60, no. 11, p. 2389-2401

Consortium of Swiss Academic Libraries

PI3Kinase signaling in glioblastoma

Lino, M. ; Merlo, A.

In: Journal of Neuro-Oncology, 2011, vol. 103, no. 3, p. 417-427