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Université de Fribourg

Patient-derived and artificial ascites have minor effects on MeT-5A mesothelial cells and do not facilitate ovarian cancer cell adhesion

Estermann, Manuela ; Huang, Yen-Lin ; Septiadi, Dedy ; Ritz, Danilo ; Liang, Ching-Yeu ; Jacob, Francis ; Drasler, Barbara ; Petri-Fink, Alke ; Heinzelmann-Schwarz, Viola ; Rothen-Rutishauser, Barbara

In: PLOS ONE, 2020, vol. 15, no. 12, p. e0241500

The presence of ascites in the peritoneal cavity leads to morphological and functional changes of the peritoneal mesothelial cell layer. Cells loose cell-cell interactions, rearrange their cytoskeleton, activate the production of fibronectin, and change their cell surface morphology in a proinflammatory environment. Moreover, ovarian cancer cell adhesion has been shown to be facilitated by...

Université de Fribourg

Application of photoclick chemistry for the synthesis of pyrazoles via 1,3‐dipolar cycloaddition between alkynes and nitrilimines generated in situ

Remy, Richard ; Bochet, Christian G.

In: European Journal of Organic Chemistry, 2018, vol. 2018, no. 3, p. 316–328

The photochemical extrusion of gaseous nitrogen from 2,5-disubstituted tetrazoles to generate reactive nitrilimines in situ represents an efficient and attractive way to form dipoles that can be used to provide useful chemicals via 1,3-dipolar cycloadditions. The concept of “photoclick chemistry” already inspired numerous researchers, who exploited photochemical processes involving...

Université de Fribourg

Photochemical C–H activation: generation of indole and carbazole libraries, and first total synthesis of clausenawalline D

Alimi, Isak ; Remy, Richard ; Bochet, Christian G.

In: European Journal of Organic Chemistry, 2017, vol. 2017, no. 22, p. 3197–3210

The photolysis of N-aryltriazoles and N-arylbenzotriazoles leads to indoles and carbazoles, respectively. Because libraries of triazoles can be accessed rapidly, for example by the copper-catalyzed [3+2] cycloaddition reaction between alkynes and azides, this reaction allows the preparation of indoles in a single operation, by the simultaneous photolysis of the precursor library. As an example of...