Università della Svizzera italiana

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

Rongvaux, Anthony ; Willinger, Tim ; Takizawa, Hitoshi ; Rathinam, Chozhavendan ; Auerbach, Wojtek ; Murphy, Andrew J. ; Valenzuela, David M. ; Yancopoulos, George D. ; Eynon, Elizabeth E. ; Stevens, Sean ; Manz, Markus G. ; Flavell, Richard A.

In: Proceedings of the national academy of sciences of the United States of America, 2011, vol. 108, no. 6, p. 2378-2383

Hematopoietic stem cells (HSCs) both self-renew and give rise to all blood cells for the lifetime of an individual. Xenogeneic mouse models are broadly used to study human hematopoietic stem and progenitor cell biology in vivo. However, maintenance, differentiation, and function of human hematopoietic cells are suboptimal in these hosts. Thrombopoietin (TPO) has been demonstrated as a crucial...

Université de Fribourg

Obesity promotes the expansion of metastasis-initiating cells in breast cancer

Bousquenaud, Mélanie ; Fico, Flavia ; Solinas, Giovanni ; Rüegg, Curzio ; Santamaria-Martínez, Albert

In: Breast Cancer Research, 2018, vol. 20, no. 1, p. 104

Obesity is a strong predictor of poor prognosis in breast cancer, especially in postmenopausal women. In particular, tumors in obese patients tend to seed more distant metastases, although the biology behind this observation remains poorly understood.Methods: To elucidate the effects of the obese microenvironment on metastatic spread, we ovariectomized C57BL/6 J female mice and fed them...

Consortium of Swiss Academic Libraries

The Mammary Gland Vasculature Revisited

Andres, Anne-Catherine ; Djonov, Valentin

In: Journal of Mammary Gland Biology and Neoplasia, 2010, vol. 15, no. 3, p. 319-328

Consortium of Swiss Academic Libraries

Therapeutic Targeting of Signal Transduction Pathways and Proteins in Breast Cancer

Hynes, Nancy ; Gullick, William

In: Journal of Mammary Gland Biology and Neoplasia, 2006, vol. 11, no. 1, p. 1-2

Consortium of Swiss Academic Libraries

Alveolar and Lactogenic Differentiation

Brisken, Cathrin ; Rajaram, Renuga

In: Journal of Mammary Gland Biology and Neoplasia, 2006, vol. 11, no. 3-4, p. 239-248