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Université de Fribourg

Asymmetric and distant effects of a unilateral lesion of the primary motor cortex on the bilateral supplementary motor areas in adult macaque monkeys

Contestabile, Alessandro. ; Colangiulo, R. ; Lucchini, Matteo ; Gindrat, Anne-Dominique ; Hamadjida, Adjia ; Kaeser, Mélanie ; Savidan, Julie ; Wyss, A. F. ; Rouiller, Eric M. ; Schmidlin, Eric

In: Journal of Neuroscience, 2018, vol. 38, no. 50, p. 10644–10656

A restricted lesion of the hand area in the primary motor cortex (M1) leads to a deficit of contralesional manual dexterity, followed by an incomplete functional recovery, accompanied by plastic changes in M1 itself and in other cortical areas on both hemispheres. Using the marker SMI-32 specific to pyramidal neurons in cortical layers III and V, we investigated the impact of a focal...

Université de Fribourg

Bimetallic metal organic frameworks with precisely positioned metal centers for efficient H2 storage

Kim, Daeok ; Song, Kyung Seob ; Buyukcakir, Onur ; Yildirim, Taner ; Coskun, Ali

In: Chemical Communications, 2018, vol. 54, no. 86, p. 12218–12221

We demonstrated that the ratio and position of two different metal ions, Pd and Cu, can be precisely controlled within MOFs through predesigned metal clusters. These MOF structures incorporating Pd–Cu paddle wheel units were synthesised simply by reacting Pd–Cu acetate metal clusters and tritopic organic linkers at room temperature. Pd–Cu open metal sites were found to be uniformly...

Université de Fribourg

Packmem: a versatile tool to compute and visualize interfacial packing defects in lipid bilayers

Gautier, Romain ; Bacle, Amélie ; Tiberti, Marion L. ; Fuchs, Patrick F. ; Vanni, Stefano ; Antonny, Bruno

In: Biophysical Journal, 2018, vol. 115, no. 3, p. 436–444

The analysis of the structural organization of lipid bilayers is generally performed across the direction normal to the bilayer/water interface, whereas the surface properties of the bilayer at the interface with water are often neglected. Here, we present PackMem, a bioinformatic tool that performs a topographic analysis of the bilayer surface from various molecular dynamics simulations....

Université de Fribourg

Evolution of longevity improves immunity in Drosophila

Fabian, Daniel K. ; Garschall, Kathrin ; Klepsatel, Peter ; Santos-Matos, Gonçalo ; Sucena, Élio ; Kapun, Martin ; Lemaitre, Bruno ; Schlötterer, Christian ; Arking, Robert ; Flatt, Thomas

In: Evolution Letters, 2018, vol. 2, no. 6, p. 567–579

Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin signaling as a major regulator of longevity, yet whether standing variation in this pathway underlies microevolutionary changes in...

Université de Neuchâtel

La gestion durable des sols agricoles : sécuriser les démarches ou légitimer les controverses ? L’exemple des politiques agroenvironnementales autour de l’érosion hydrique des sols arables en Suisse

Derungs, Nicolas ; Hertz, Ellen (Dir.) ; Mitchell, Edward (Codir.)

Thèse de doctorat : Université de Neuchâtel, 2018 ; TH. 2722.

Cette recherche interdisciplinaire (sciences naturelles – sciences politiques et sociales) porte sur la thématique de la gestion durable des sols agricoles. Plus spécifiquement, elle s’est focalisée sur les politiques environnementales et agricoles suisses autour de la protection qualitative des sols et de la lutte contre de l’érosion hydrique des sols arables. L’étude a abouti...

Haute école de santé Genève

Quelle est l'importance du sommeil dans la prise en charge des patients diabétiques de type 2 et quelles recommandations pour la pratique clinique d'un diététicien ? : travail de Bachelor

Emanuel, Gensiga ; Equey, Julie ; Kehl Dubois, Corinne (Dir.)

Mémoire de bachelor : Haute école de santé Genève, 2018.

Introduction : Le diabète de type 2 est une maladie non transmissible touchant près de 360’000 individus en Suisse. Les troubles du sommeil touchent près d’un quart de la population suisse. L’American Diabetes Association recommande que l’évaluation du sommeil fasse partie intégrante de l’anamnèse du patient diabétique de type 2. But : Le but de ce travail de Bachelor est de...

Université de Fribourg

Interaction of the hydrogen sulfide system with the oxytocin system in the injured mouse heart

Merz, Tamara ; Lukaschewski, Britta ; Wigger, Daniela ; Rupprecht, Aileen ; Wepler, Martin ; Gröger, Michael ; Hartmann, Clair ; Whiteman, Matthew ; Szabo, Csaba ; Wang, Rui ; Waller, Christiane ; Radermacher, Peter ; McCook, Oscar

In: Intensive Care Medicine Experimental, 2018, vol. 6, no. 1, p. 41

Both the hydrogen sulfide/cystathionine-γ-lyase (H2S/CSE) and oxytocin/oxytocin receptor (OT/OTR) systems have been reported to be cardioprotective. H2S can stimulate OT release, thereby affecting blood volume and pressure regulation. Systemic hyper-inflammation after blunt chest trauma is enhanced in cigarette smoke (CS)-exposed CSE−/− mice compared to wildtype (WT). CS increases...

Université de Fribourg

Comparison of climatic trends and variability among glacierized environments in the Western Himalayas

Dimri, A. P. ; Immerzeel, W. W. ; Salzmann, Nadine ; Thayyen, R. J.

In: Theoretical and Applied Climatology, 2018, vol. 134, no. 1, p. 155–163

The climate and hydrology of the Western Himalayas is complex and a function of snow and glacier melt, land use, topography, and Indian summer and winter monsoon dynamics. Improving our knowledge about these processes is important from societal and agricultural points of view. In this study, an observational analysis is carried out to assess the changing climatic trends and the associated...

Haute école de santé Genève

Radioprotection opérationnelle pour la réalisation des scintigraphies myocardiques aux Hôpitaux Universitaires de Genève : travail de Bachelor

Caruso, Moïra ; Gnerro, Ursulla ; Jeandet, Justine ; Fleury, Eric (Dir.)

Mémoire de bachelor : Haute école de santé Genève, 2018.

Les maladies cardiovasculaires représentent aujourd'hui la première cause de décès dans les pays développés dont la Suisse. Ces maladies sont caractérisées par une atteinte du cœur ainsi que des vaisseaux de l'organisme et plus particulièrement des artères coronaires qui nourrissent le muscle cardiaque, le myocarde. Ce sont principalement des maladies qui évoluent dans le temps, leurs...

Université de Neuchâtel

How many Migrants does the Swiss Pension System Need?

Milivinti, Alice

(nccr on the move ; 19)

The positive role exerted by migrants to decelerate the ageing population process of devel oped countries has been stressed by many studies. However, the actual number of migrants needed to sustain the pension systems and its effectiveness in the long-run often remains tacit. While assuming the increment of the retired population to be the only shock, this study un dertakes an accounting exercise...