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Université de Fribourg

Life-history evolution and the polyphenic regulation of somatic maintenance and survival

Flatt, Thomas ; Amdam, Gro V. ; Kirkwood, Thomas B. L. ; Omholt, Stig W.

In: The Quarterly Review of Biology, 2013, vol. 88, no. 3, p. 185–218

Here we discuss life-history evolution from the perspective of adaptive phenotypic plasticity, with a focus on polyphenisms for somatic maintenance and survival. Polyphenisms are adaptive discrete alternative phenotypes that develop in response to changes in the environment. We suggest that dauer larval diapause and its associated adult phenotypes in the nematode (Caenorhabditis elegans),...

Université de Fribourg

Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America

Fabian, Daniel K. ; Kapun, Martin ; Nolte, Viola ; Kofler, Robert ; Schmidt, Paul S. ; Schlötterer, Christian ; Flatt, Thomas

In: Molecular Ecology, 2012, vol. 21, no. 19, p. 4748–4769

Understanding the genetic underpinnings of adaptive change is a fundamental but largely unresolved problem in evolutionary biology. Drosophila melanogaster, an ancestrally tropical insect that has spread to temperate regions and become cosmopolitan, offers a powerful opportunity for identifying the molecular polymorphisms underlying clinal adaptation. Here, we use genome‐wide next‐...

Università della Svizzera italiana

CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons

Abe, Philipp ; Mueller, Wiebke ; Schütz, Dagmar ; MacKay, Fabienne ; Thelen, Marcus ; Zhang, Penglie ; Stumm, Ralf

In: Development, 2014, vol. 141, no. 9, p. 1857-1863

The CXCL12/CXCR4 signaling pathway is involved in the development of numerous neuronal and non-neuronal structures. Recent work established that the atypical second CXCL12 receptor, CXCR7, is essential for the proper migration of interneuron precursors in the developing cerebral cortex. Two CXCR7-mediated functions were proposed in this process: direct modulation of β-arrestin-mediated...

Università della Svizzera italiana

A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation

De Muyt, Arnaud ; Pyatnitskaya, Alexandra ; Andréani, Jessica ; Ranjha, Lepakshi ; Laureau, Raphaëlle ; Fernandez-Vega, Ambra ; Holoch, Daniel ; Girard, Elodie ; Govin, Jérome ; Margueron, Raphaël ; Couté, Yohann ; Cejka, Petr ; Guérois, Raphaël ; Borde, Valérie

In: Genes and development, 2018, vol. 32, no. 3-4, p. 283-296

Meiotic crossover formation requires the stabilization of early recombination intermediates by a set of proteins and occurs within the environment of the chromosome axis, a structure important for the regulation of meiotic recombination events. The molecular mechanisms underlying and connecting crossover recombination and axis localization are elusive. Here, we identified the ZZS...

Université de Neuchâtel

Analysing Implicit Premises Within Children’s Argumentative Inferences

Greco, Sara ; Perret-Clermont, Anne-Nelly ; Iannaccone, Antonio ; Rocci, Andrea ; Convertini, Josephine ; Schär, Rebecca G.

In: Argumentation and Inference: Proceedings of the 2nd European Conference on Argumentation, Fribourg 2017, 2017, vol. 1, no. 7, p. 147-167

This paper presents preliminary findings of the project “Analysing children’s implicit argumentation”. We propose to reconstruct implicit premises of children’s arguments within adult-children discussions in different settings, using the Argumentum Model of Topics (AMT) for the reconstruction of the inferential configuration of arguments. We show that sources of misunderstandings are more...

Université de Neuchâtel

Etre élève et exprimer une pensée propre: un paradoxe ?

Breux, Stéphanie ; Perret-Clermont, Anne-Nelly

In: Enseignement du français: les apports de la recherche en linguistique. Réflexions en l'honneur de Marie-José Béguelin, 2014, p. 327-340

Université de Neuchâtel

Do Swiss Citizens of Immigrant Origin Face Hiring Discrimination in the Labour Market?

Zschirnt, Eva ; Fibbi, Rosita

(nccr on the move ; 20)

The extent to which discrimination in employment disadvantages children of immigrants is a major question both in economic research on labour market and in sociological studies of integration. This working paper contributes to the debate by reporting findings of a correspondence test in which pairs of equally qualified Swiss citizens –one from the majority group and one from one minority...