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Consortium of Swiss Academic Libraries

Exploring Leave Policy Preferences: A Comparison of Austria, Sweden, Switzerland, and the United States

Valarino, Isabel ; Duvander, Ann-Zofie ; Haas, Linda ; Neyer, Gerda

In: Social Politics: International Studies in Gender, State & Society, 2018, vol. 25, no. 1, p. 118-147

Università della Svizzera italiana

Protein environment : a crucial triggering factor in Josephin domain aggregation : the role of 2,2,2-trifluoroethanol

Visentin, Cristina ; Navarro, Susanna ; Grasso, Gianvito ; Regonesi, Maria Elena ; Deriu, Marco Agostino ; Tortora, Paolo ; Ventura, Salvador

In: International journal of molecular sciences, 2018, vol. 19, no. 8, p. 2151

The protein ataxin-3 contains a polyglutamine stretch that triggers amyloid aggregation when it is expanded beyond a critical threshold. This results in the onset of the spinocerebellar ataxia type 3. The protein consists of the globular N-terminal Josephin domain and a disordered C-terminal tail where the polyglutamine stretch is located. Expanded ataxin-3 aggregates via a two-stage...

Université de Fribourg

Cost-effectiveness of drug-eluting stents in elderly patients with coronary artery disease: the SENIOR trial

Bulsei, Julie ; Butel, Thibault ; Varenne, Olivier ; Cook, Stéphane ; Cuisset, Thomas ; Carrié, Didier ; Hovasse, Thomas ; Morice, Marie-Claude ; Sinnaeve, Peter R. ; Durand-Zaleski, Isabelle

In: Value in Health, 2019, vol. 22, no. 12, p. 1355–1361

Elderly patients receive bare metal stents instead of drug-eluting stents (DES) to shorten the duration of dual antiplatelet therapy (DAPT). The SENIOR trial compared outcomes between these 2 types of stents combined with a short duration of DAPT. A significant decrease in the number of patients with at least 1 major adverse cardiac and cerebrovascular event (MACCE) was noted in the DES...

Université de Fribourg

Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides

Gabryelczyk, Bartosz ; Cai, Hao ; Shi, Xiangyan ; Sun, Yue ; Swinkels, Piet J.M. ; Salentinig, Stefan ; Pervushin, Konstantin ; Miserez, Ali

In: Nature Communications, 2019, vol. 10, no. 1, p. 1–12

Liquid-liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) is involved in both intracellular membraneless organelles and extracellular tissues. Despite growing understanding of LLPS, molecular-level mechanisms behind this process are still not fully established. Here, we use histidine-rich squid beak proteins (HBPs) as model IDPs to shed light on molecular interactions...