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Università della Svizzera italiana

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects

Rigoni, Rosita ; Fontana, Elena ; Guglielmetti, Simone ; Fosso, Bruno ; D’Erchia, Anna Maria ; Maina, Virginia ; Taverniti, Valentina ; Carmina Castiello, Maria ; Mantero, Stefano ; Pacchiana, Giovanni ; Musio, Silvia ; Pedotti, Rosetta ; Selmi, Carlo ; Mora, J. Rodrigo ; Pesole, Graziano ; Vezzoni, Paolo ; Poliani, Pietro Luigi ; Grassi, Fabio ; Villa, Anna ; Cassani, Barbara

In: The journal of experimental medicine, 2016, vol. 213, no. 3, p. 355-375

Omenn syndrome (OS) is caused by hypomorphic Rag mutations and characterized by a profound immunodeficiency associated with autoimmune-like manifestations. Both in humans and mice, OS is mediated by oligoclonal activated T and B cells. The role of microbial signals in disease pathogenesis is debated. Here, we show that Rag2R229Q knock-in mice developed an inflammatory bowel disease affecting...

Université de Fribourg

Direct and indirect effects of training vouchers for the unemployed

Huber, Martin ; Lechner, Michael ; Strittmatter, Anthony

In: Journal of the Royal Statistical Society Series A, 2018, vol. 181, no. 2, p. 441-463

This paper evaluates the effects of awarding vouchers for vocational training on the employment outcomes of unemployed voucher recipients in Germany, as well as the potential mechanism through which they operate. This study assesses the direct effects of voucher assignment net of actual redemption, which may be driven by preference shaping and learning about possible human capital investments...

Université de Fribourg

Should Welfare Administration be Centralized or Decentralized? : Evidence from a Policy Experiment

Boockmann, Bernhard ; Thomson, Stephan L. ; Walter, Thomas ; Göbel, Christian ; Huber, Martin

In: German economic review, 2013, vol. 16, no. 1, p. 13-42

The 2005 reform of the German welfare system introduced two competing organizational models for welfare administration. In most districts, a centralized organization was established where local welfare agencies are bound to central directives. At the same time, 69 districts were allowed to opt for a decentralized organization. We evaluate the relative success of both types in terms of...

Université de Neuchâtel

The impact of official development assistance on the donor's economy : the case of Switzerland

López, Luciano ; Zarin-Nejadan, Milad (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018 ; 2696.

Cette thèse analyse l'impact économique de l'Aide Publique au Développement (APD) sur le pays donateur pour le cas de la Suisse. Comme première étape, le chapitre 1 discute d'une approche « flux de fonds » pour quantifier l'impact de l'APD bilatérale et multilatérale sur l'économie du pays donateur. Cette méthodologie simple mais rigoureuse, permet de calculer l'impact primaire...

Université de Fribourg

Do German Welfare-to-Work Programmes Reduce Welfare Dependency and Increase Employment?

Huber, Martin ; Lechner, Michael ; Wunsch, Conny ; Walter, Thomas

In: German economic review, 2011, vol. 12, no. 2, p. 182-204

During the last decade, many Western economies reformed their welfare systems with the aim of activating welfare recipients by increasing welfare-to-work programmes (WTWP) and job-search enforcement. We evaluate the short-term effects of three important German WTWP implemented after a major reform in January 2005 (‘Hartz IV’), namely short training, further training with a planned...

Université de Fribourg

Does leaving welfare improve health? Evidence for Germany

Huber, Martin ; Lechner, Michael ; Wunsch, Conny

In: Health economics, 2011, vol. 20, no. 4, p. 484-504

Using exceptionally rich linked administrative and survey information on German welfare recipients we investigate the health effects of transitions from welfare to employment and of assignments to welfare-to-work programmes. Applying semi- parametric propensity score matching estimators we find that employment substantially increases (mental) health. The positive effects are mainly driven by ...

Université de Fribourg

Integrase-mediated recombination of the bel-1 gene cassette encoding the extended-spectrum β-lactamase BEL-1

Bouheraoua, Nacim ; Poirel, Laurent ; Bourreau, Baptiste ; Bonnin, Rémy ; Laroche, Laurent ; Naas, Thierry ; Nordmann, Patrice

In: Antimicrobial Agents and Chemotherapy, 2018, p. AAC.00030-18

Integrons are genetic elements that can acquire and rearrange gene cassettes. The blaBEL-1 gene encodes an extended-spectrum β-lactamase, BEL-1, that is present at second position of the variable region of class 1 integrons identified in Pseudomonas aeruginosa. The mobility of the bel-1 gene cassette was analyzed in physiological conditions and with the integrase gene being overexpressed....

Università della Svizzera italiana

Beyond the knowledge gap paradigm : the role of psychological empowerment in parents’ vaccination decision

Fadda, Marta ; Schulz, Peter J. (Dir.)

Thèse de doctorat : Università della Svizzera italiana, 2017 ; 2017COM008.

Even though the efficacy and safety of immunization have been widely proven (Plotkin, 2014), an increasing number of parents have refused to vaccinate their children against serious infectious diseases in the past twenty years (Dubé, Gagnon, Nickels, Jeram, & Schuster, 2014). A recent shift in the study of vaccination decision- making has seen scholars moving beyond the idea that mere lack of...

Université de Neuchâtel

Referential gestures in fish collaborative hunting

Vail, Alexander L ; Manica, Andrea ; Bshary, Redouan

In: Nature Communications, 2013, vol. 4, p. 1765

In humans, referential gestures intentionally draw the attention of a partner to an object of mutual interest, and are considered a key element in language development. Outside humans, referential gestures have only been attributed to great apes and, most recently, ravens. This was interpreted as further evidence for the comparable cognitive abilities of primates and corvids. Here we describe a...

Université de Neuchâtel

Resolution of experimental and tick-borne Borrelia burgdorferi infection in mice by passive, but not active immunization using recombinant OspC

Zhong, Weimin ; Gern, Lise ; Stehle, Thomas ; Museteanu, Crisan ; Kramer, Michael ; Wallich, Reinhard ; Simon, Markus M

In: European Journal of Immunology, 1999, vol. 29, no. 3, p. 946-957

Vaccination with outer surface protein A (OspA) of Borrelia burgdorferi prevents subsequent infection and disease in both laboratory animals and humans with high efficacy. OspA-based immunity, however, does not affect established infection due to the loss of OspA expression in the vertebrate host. We show here that repeated passive transfer of mouse and/or rabbit immune sera to...