Affiner les résultats

In Vivo Longitudinal 1H MRS Study of Transgenic Mouse Models of Prion Disease in the Hippocampus and Cerebellum at 14.1T

Cudalbu, Cristina ; Craveiro, Melanie ; Mlynárik, Vladimir ; Bremer, Juliane ; Aguzzi, Adriano ; Gruetter, Rolf

In: Neurochemical Research, 2015, vol. 40, no. 12, p. 2639-2646

Synaptic Adhesion Molecules Regulate the Integration of New Granule Neurons in the Postnatal Mouse Hippocampus and their Impact on Spatial Memory

Krzisch, Marine ; Fülling, Christine ; Jabinet, Laura ; Armida, Jan ; Gebara, Elias ; Cassé, Frédéric ; Habbas, Samia ; Volterra, Andrea ; Hornung, Jean-Pierre ; Toni, Nicolas

In: Cerebral Cortex, 2017, vol. 27, no. 8, p. 4048-4059

Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome

Moutin, E. ; Nikonenko, I. ; Stefanelli, T. ; Wirth, A. ; Ponimaskin, E. ; De Roo, M. ; Muller, D.

In: Cerebral Cortex, 2017, vol. 27, no. 7, p. 3618-3629

Association between Cortical GABA and Loudness Dependence of Auditory Evoked Potentials (LDAEP) in Humans

Wyss, Christine ; Tse, Desmond H Y. ; Boers, Frank ; Shah, Nadim J. ; Neuner, Irene ; Kawohl, Wolfram

In: International Journal of Neuropsychopharmacology, 2018, vol. 21, no. 9, p. 809-813

Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus

Krzisch, Marine ; Temprana, Silvio ; Mongiat, Lucas ; Armida, Jan ; Schmutz, Valentin ; Virtanen, Mari ; Kocher-Braissant, Jacqueline ; Kraftsik, Rudolf ; Vutskits, Laszlo ; Conzelmann, Karl-Klaus ; Bergami, Matteo ; Gage, Fred ; Schinder, Alejandro ; Toni, Nicolas

In: Brain Structure and Function, 2015, vol. 220, no. 4, p. 2027-2042

Gene expression analysis in the mouse brainstem identifies Cart and Nesfatin as neuropeptides coexpressed in the Calbindin-positive neurons of the Nucleus papilio

Girard, Franck ; von Siebenthal, Michelle ; Davis, Fred P. ; Celio, Marco R.

In: Sleep, 2020, vol. 43, no. 2020-11, p. zsaa085

Study Objectives: The brainstem contains several neuronal populations, heterogeneous in terms of neurotransmitter/neuropeptide content, which are important for controlling various aspects of the rapid eye movement (REM) phase of sleep. Among these populations are the Calbindin (Calb)-immunoreactive NPCalb neurons, located in the Nucleus papilio, within the dorsal paragigantocellular nucleus...

Parvalbumin-deficiency accelerates the age-dependent ROS production in Pvalb neurons in vivo: link to neurodevelopmental disorders

Janickova, Lucia ; Schwaller, Beat

In: Frontiers in Cellular Neuroscience, 2020, vol. 14, p. -

In neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD) and schizophrenia, impairment/malfunctioning of a subpopulation of interneurons expressing the calcium-binding protein parvalbumin (PV) –here termed Pvalb neurons– has gradually emerged as a possible cause. These neurons may represent a hub or point-of-convergence in the etiology of NDD. Increased oxidative...

Absence of parvalbumin increases mitochondria volume and branching of dendrites in inhibitory Pvalb neurons in vivo: a point of convergence of autism spectrum disorder (ASD) risk gene phenotypes

Janickova, Lucia ; Rechberger, Karin Farah ; Wey, Lucas ; Schwaller, Beat

In: Molecular Autism, 2020, vol. 11, no. 1, p. 47

In fast firing, parvalbumin (PV)-expressing (Pvalb) interneurons, PV acts as an intracellular Ca2+ signal modulator with slow-onset kinetics. In Purkinje cells of PV−/− mice, adaptive/homeostatic mechanisms lead to an increase in mitochondria, organelles equally capable of delayed Ca2+ sequestering/buffering. An inverse regulation of PV and mitochondria likewise operates in cell model...

Differential expression of CD31 and von Willebrand factor on endothelial cells in different regions of the human brain: potential implications for cerebral malaria pathogenesis

Mbagwu, Smart Ikechukwu ; Filgueira, Luis

In: Brain Sciences, 2020, vol. 10, no. 1, p. 31

Cerebral microvascular endothelial cells (CMVECs) line the vascular system of the brain and are the chief cells in the formation and function of the blood brain barrier (BBB). These cells are heterogeneous along the cerebral vasculature and any dysfunctional state in these cells can result in a local loss of function of the BBB in any region of the brain. There is currently no report on the...

Profiling parvalbumin interneurons using iPSC: challenges and perspectives for Autism Spectrum Disorder (ASD)

Filice, Federica ; Schwaller, Beat ; Michel, Tanja M. ; Grünblatt, Edna

In: Molecular Autism, 2020, vol. 11, no. 1, p. 10

Autism spectrum disorders (ASD) are persistent conditions resulting from disrupted/altered neurodevelopment. ASD multifactorial etiology—and its numerous comorbid conditions—heightens the difficulty in identifying its underlying causes, thus obstructing the development of effective therapies. Increasing evidence from both animal and human studies suggests an altered functioning of the...