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Université de Fribourg

Increased resistance to carbapenems in proteus mirabilis mediated by amplification of the bla vim-1 -carrying and is 26 -associated class 1 integron

Bontron, Séverine ; Poirel, Laurent ; Kieffer, Nicolas ; Savov, Encho ; Trifonova, Angelina ; Todorova, Iva ; Kueffer, Gwendoline ; Nordmann, Patrice

In: Microbial Drug Resistance, 2019, vol. 25, no. 5, p. 663–667

The aim of the study was to decipher the mechanisms and associated genetic determinants responsible for increased carbapenem resistance among Proteus mirabilis clinical isolates.Methods: The entire genetic structure surrounding the β- lactam resistance genes was characterized by PCR, gene walking, and DNA sequencing.Results: A series of clinical P. mirabilis isolates were consecutively ...

Université de Fribourg

Tautomerism as primary signaling mechanism in metal sensing: the case of amide group

Deneva, Vera ; Dobrikov, Georgi ; Crochet, Aurélien ; Nedeltcheva, Daniela ; Fromm, Katharina M. ; Antonov, Liudmil

In: Beilstein Journal of Organic Chemistry, 2019, vol. 15, no. 1, p. 1898–1906

The concept for sensing systems using the tautomerism as elementary signaling process has been further developed by synthesizing a ligand containing 4- (phenyldiazenyl)naphthalene-1-ol as a tautomeric block and an amide group as metal capturing antenna. Although it has been expected that the intramolecular hydrogen bonding (between the tautomeric hydroxy group and the nitrogen atom from the...

Université de Fribourg

A rational and iterative process for targeted nanoparticle design and validation

Rodriguez-Lorenzo, Laura ; Rafiee, Sarah D. ; Reis, Corine ; Milosevic, Ana ; Moore, Thomas L. ; Balog, Sandor ; Rothen-Rutishauser, Barbara ; Rüegg, Curzio ; Petri-Fink, Alke

In: Colloids and Surfaces B: Biointerfaces, 2018, vol. 171, p. 579–589

The lack of understanding of fundamental nano-bio interactions, and difficulties in designing particles stable in complex biological environments are major limitations to their translation into biomedical clinical applications. Here we present a multi- parametric approach to fully characterize targeted nanoparticles, and emphasizes the significant effect that each detail in the synthetic...

Consortium of Swiss Academic Libraries

Myc and Mammary Cancer: Myc is a Downstream Effector of the ErbB2 Receptor Tyrosine Kinase

Hynes, Nancy ; Lane, Heidi

In: Journal of Mammary Gland Biology and Neoplasia, 2001, vol. 6, no. 1, p. 141-150