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Accès public à partir du 30 janv. 2020
Università della Svizzera italiana

The contribution of active and passive mechanisms of 5mC and 5hmC removal in human T lymphocytes is differentiation- and activation-dependent

Vincenzetti, Lucia ; Leoni, Cristina ; Chirichella, Michele ; Kwee, Ivo ; Monticelli, Silvia

In: European Journal of Immunology, 2019, p. 1-15

In mammals, the 5’-methylcytosine (5mC) modification in the genomic DNA contributes to the dynamic control of gene expression. 5mC erasure is required for the activation of developmental programs and occurs either by passive dilution through DNA replication, or by enzymatic oxidation of the methyl mark to 5-hydroxymethylcytosine (5hmC), which can persist as such or undergo further oxidation...

Université de Fribourg

T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field

Sanz‑Ortega, Laura ; Rojas, José M. ; Marcos, Ana ; Portilla, Yadileiny ; Stein, Jens V. ; Barber, Domingo F.

In: Journal of Nanobiotechnology, 2019, vol. 17, no. 1, p. 14

T lymphocytes are highly dynamic elements of the immune system with a tightly regulated migration. T cell-based transfer therapies are promising therapeutic approaches which in vivo efficacy is often limited by the small proportion of administered cells that reaches the region of interest. Manipulating T cell localisation to improve specific targeting will increase the effectiveness of these...

Université de Neuchâtel

Isotope fractionation due to diffusion and sorption of chlorinated hydrocarbons and its implications for identifying reactive processes in aquifer - aquitard systems

Wanner, Philipp ; Hunkeler, Daniel (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2016.

Des méthodes isotopiques stables ont été utilisées de plus en plus pour identifier et quantifier la transformation réactive dans la sous-surface de composés organiques tels que les hydrocarbures chlorés. La méthode générale repose sur l'hypothèse que seuls les processus réactifs sont associés à un effet isotopique. Cependant, des études récentes ont révélé que les processus...

Université de Neuchâtel

Action selectors without Floer-Homology

Haug, Carsten ; Schlenk, Felix (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Les systèmes hamiltoniens sur des variétés symplectiques ont d'habitude beaucoup d'orbites périodiques. Les actions des orbites forment un invariant du système hamiltonien. Cependant, l'ensemble des actions peut être très grand. Pour obtenir des invariants utiles, on ne sélectionne pour chaque fonction hamiltonienne qu'une valeur d'action en utilisant une procédure de minimax : on...

Université de Neuchâtel

On reducing latency in geo-distributed systems through state partitioning and caching

Halalai, Raluca ; Felber, Pascal (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Les systèmes distribués modernes sont de plus en plus grands, et sont déployés dans plusieurs régions géographiques. L’objectif final de tels systèmes est de fournir des services à leurs utilisateurs ainsi que haute disponibilité et bonne performance. Cette thèse propose des techniques pour réduire le latence perçue par des utilisateurs. Pour commencer, nous...

Université de Fribourg

Spontaneously orbital-selective superconductivity in a three-orbital Hubbard model

Ishigaki, Kosuke ; Nasu, Joji ; Koga, Akihisa ; Hoshino, Shintaro ; Werner, Philipp

In: Physical Review B, 2018, vol. 98, no. 23, p. 235120

We study a three-orbital Hubbard model with negative Hund's coupling in infinite dimensions, combining dynamical mean-field theory with continuous time quantum Monte Carlo simulations. This model, which is relevant for the description of alkali- doped fullerides, has previously been shown to exhibit a spontaneous orbital-selective Mott phase in the vicinity of the superconducting phase....

Université de Fribourg

Physically based hydrogeological and slope stability modeling of the Turaida castle mound

Kukemilks, Karlis ; Wagner, Jean-Frank ; Saks, Tomas ; Brunner, Philip

In: Landslides, 2018, vol. 15, no. 11, p. 2267–2278

This study explores the potential of integrating state-of-the-art physically based hydrogeological modeling into slope stability simulations to identify the hydrogeological triggers of landslides. Hydrogeological models considering detailed morphological, lithological, and climatic factors were elaborated. Groundwater modeling reveals locations with elevated pore water pressures in the...

Université de Fribourg

Packmem: a versatile tool to compute and visualize interfacial packing defects in lipid bilayers

Gautier, Romain ; Bacle, Amélie ; Tiberti, Marion L. ; Fuchs, Patrick F. ; Vanni, Stefano ; Antonny, Bruno

In: Biophysical Journal, 2018, vol. 115, no. 3, p. 436–444

The analysis of the structural organization of lipid bilayers is generally performed across the direction normal to the bilayer/water interface, whereas the surface properties of the bilayer at the interface with water are often neglected. Here, we present PackMem, a bioinformatic tool that performs a topographic analysis of the bilayer surface from various molecular dynamics simulations....

Accès public à partir du 15 janv. 2021
Università della Svizzera italiana

Modelling protein-protein interactions to elucidate molecular mechanisms behind neurodegenerative diseases

Grasso, Gianvito ; Krause, Rolf (Dir.) ; Danani, Andrea (Codir.)

Thèse de doctorat : Università della Svizzera italiana, 2018 ; 2018INFO017.

The worldwide significant increase in life expectancy has recently drawn the attention of the scientific community to neurodegenerative pathologies of the elderly population. These neurodegenerative disorders arise from the abnormal protein aggregation in the nervous tissue leading to intracellular inclusions or extracellular aggregates in specific brain areas. A feasible strategy to prevent...

Université de Fribourg

The diversity of population responses to environmental change

Colchero, Fernando ; Jones, Owen R. ; Conde, Dalia A. ; Hodgson, David ; Zajitschek, Felix ; Schmidt, Benedikt R. ; Malo, Aurelio F. ; Alberts, Susan C. ; Becker, Peter H. ; Bouwhuis, Sandra ; Bronikowski, Anne M. ; Vleeschouwer, Kristel M. ; Delahay, Richard J. ; Dummermuth, Stefan ; Fernández‐Duque, Eduardo ; Frisenvænge, John ; Hesselsøe, Martin ; Larson, Sam ; Lemaître, Jean‐François ; McDonald, Jennifer ; Miller, David A.W. ; O'Donnell, Colin ; Packer, Craig ; Raboy, Becky E. ; Reading, Chris J. ; Wapstra, Erik ; Weimerskirch, Henri ; While, Geoffrey M. ; Baudisch, Annette ; Flatt, Thomas ; Coulson, Tim ; Gaillard, Jean‐Michel

In: Ecology Letters, 2019, p. -

The current extinction and climate change crises pressure us to predict population dynamics with ever‐greater accuracy. Although predictions rest on the well‐advanced theory of age‐structured populations, two key issues remain poorly explored. Specifically, how the age‐dependency in demographic rates and the year‐to‐year interactions between survival and fecundity affect...