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Université de Fribourg

Theory of photoinduced ultrafast switching to a spin-orbital ordered hidden phase

Li, Jiajun ; Strand, Hugo U.R. ; Werner, Philipp ; Eckstein, Martin

In: Nature Communications, 2018, vol. 9, no. 1, p. 4581

Photo-induced hidden phases are often observed in materials with intertwined orders. Understanding the formation of these non-thermal phases is challenging and requires a resolution of the cooperative interplay between different orders on the ultra-short timescale. In this work, we demonstrate that non-equilibrium photo-excitations can induce a state with spin-orbital orders entirely...

Université de Fribourg

Expression of granulisyn, perforin and granzymes in human milk over lactation and in the case of maternal infection

Twigger, Alecia-Jane ; Küffer, Gwendoline K. ; Geddes, Donna T. ; Filgueria, Luis

In: Nutrients, 2018, vol. 10, no. 9, p. 1230

Human milk has been previously found to contain various types of leukocytes however specific characteristics of these cells, such as whether they contain cytolytic antimicrobial proteins that may induce pathogen directed cell death, are unknown. This project aims to examine the presence and localization of immune proteins such as perforin, granulysin and granzymes in human milk cells at the...

Université de Fribourg

Lentiviral-mediated let-7d microRNA overexpression induced anxiolytic- and anti-depressant-like behaviors and impaired dopamine D3 receptor expression

Bahi, Amine ; Dreyer, Jean-Luc

In: European Neuropsychopharmacology, 2018, vol. 28, no. 12, p. 1394–1404

Generalized anxiety and major depression disorders (MDD) are severe debilitating mood disorders whose etiology are not fully understood, but growing evidence indicates that microRNAs (miRNAs) might play a key role in their neuropathophysiological mechanisms. In the current study, we investigate the role of Lethal-7 (let-7d) miRNA, and its direct target dopamine D3 receptor (D3R) gain-of-...

Université de Fribourg

Revealing the role of epithelial mechanics and macrophage clearance during pulmonary epithelial injury recovery in the presence of carbon nanotubes

Septiadi, Dedy ; Abdussalam, Wildan ; Rodriguez‐Lorenzo, Laura ; Spuch‐Calvar, Miguel ; Bourquin, Joël ; Petri‐Fink, Alke ; Rothen‐Rutishauser, Barbara

In: Advanced Materials, 2018, vol. 30, no. 52, p. 1806181

Wound healing assays are extensively used to study tissue repair mechanisms; they are typically performed by means of physical (i.e., mechanical, electrical, or optical) detachment of the cells in order to create an open space in which live cells can lodge. Herein, an advanced system based on extensive photobleaching‐induced apoptosis; providing a powerful tool to understand the repair...

Université de Neuchâtel

Social behaviour, stress and parasites : comparing free-ranging wolves in Yellowstone (USA), Abruzzo (Italy) and Mercantour (France) national parks

Molnar, Barbara ; Betschart, Bruno (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2012.

Occupant autrefois la majeure partie de l’hémisphère nord, les populations de loups (Canis lupus) ont disparu dans une importante partie de leur aire de distribution initiale, consécutivement à la persécution humaine. Suite à la protection de l’espèce, le carnivore a récemment étendu son aire de distribution, par des mouvements de dispersion ou au travers de programmes de...

Université de Fribourg

The impact of ESCRT on Aβ1-42 induced membrane lesions in a yeast model for Alzheimer’s disease

Fruhmann, Gernot ; Marchal, Christelle ; Vignaud, Hélène ; Verduyckt, Mathias ; Talarek, Nicolas ; De Virgilio, Claudio ; Winderickx, Joris ; Cullin, Christophe

In: Frontiers in Molecular Neuroscience, 2018, vol. 11, p. -

Aβ metabolism plays a pivotal role in Alzheimer’s disease. Here, we used a yeast model to monitor Aβ42 toxicity when entering the secretory pathway and demonstrate that processing in, and exit from the endoplasmic reticulum (ER) is required to unleash the full Aβ42 toxic potential. Consistent with previously reported data, our data suggests that Aβ42 interacts with mitochondria, thereby...

Université de Fribourg

Two pairs of drosophila central brain neurons mediate larval navigational strategies based on temporal light information processing

Humberg, Tim-Henning ; Sprecher, Simon G.

In: Frontiers in Behavioral Neuroscience, 2018, vol. 12, p. -

Some animals are attracted by sun light, others are highly repulsed by it. Especially for slowly moving animals, such as Drosophila larvae, direct sunlight may be perceived as noxious stimulus as it increases the risk of desiccation, DNA-damaging by UV-light and exposure to predators. For several reasons, model organisms like Drosophila larvae are well-suited for investigating how light cues...

Université de Fribourg

Conventional and emerging roles of the energy sensor Snf1/AMPK in Saccharomyces cerevisiae

Coccetti, Paola ; Nicastro, Raffaele ; Tripodi, Farida

In: Microbial Cell, 2018, vol. 5, no. 11, p. 482–494

All proliferating cells need to match metabolism, growth and cell cycle progression with nutrient availability to guarantee cell viability in spite of a changing environment. In yeast, a signaling pathway centered on the effector kinase Snf1 is required to adapt to nutrient limitation and to utilize alternative carbon sources, such as sucrose and ethanol. Snf1 shares evolutionary conserved...

Université de Fribourg

Microbial life in the grapevine: what can we expect from the leaf microbiome?

Vionnet, Léo ; Vrieze, Mout De ; Dutartre, Agnès ; Gfeller, Aurélie ; Lüthi, Angelika ; L’Haridon, Floriane ; Weisskopf, Laure

In: OENO One, 2018, vol. 52, no. 3, p. 219–224

Recent studies have shown that plants harbor complex bacterial communities, the so- called “microbiome”. We are only beginning to unravel the origin of these bacterial plant inhabitants, their community structure and their roles, which, in analogy to the gut microbiome, are likely to be of essential nature. The aim of this work was to analyze the abundance and diversity of the cultivable...

Université de Fribourg

Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe

Contreras, Esteban G. ; Egger, Boris ; Gold, Katrina S. ; Brand, Andrea H.

In: Neural Development, 2018, vol. 13, no. 1, p. 25

Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cells progress through two transient progenitor states, PI and PII, before transforming into neuroblasts. Here we analyse the role of Notch signalling in the transition from neuroepithelial...