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Université de Fribourg

The rise of angiosperms pushed conifers to decline during global cooling

Condamine, Fabien L. ; Silvestro, Daniele ; Koppelhus, Eva B. ; Antonelli, Alexandre

In: Proceedings of the National Academy of Sciences, 2020, vol. 117, no. 46, p. 28867–28875

Competition among species and entire clades can impact species diversification and extinction, which can shape macroevolutionary patterns. The fossil record shows successive biotic turnovers such that a dominant group is replaced by another. One striking example involves the decline of gymnosperms and the rapid diversification and ecological dominance of angiosperms in the Cretaceous. It is...

Université de Fribourg

Neuroanatomy of the spinosaurid Irritator challengeri (Dinosauria: Theropoda) indicates potential adaptations for piscivory

Schade, Marco ; Rauhut, Oliver W. M. ; Evers, Serjoscha W.

In: Scientific Reports, 2020, vol. 10, no. 1, p. 9259

Spinosauridae, a theropod group characterized by elongated snouts, conical teeth, enlarged forelimbs, and often elongated neural spines, show evidence for semiaquatic adaptations and piscivory. It is currently debated if these animals represent terrestrial carnivores with adaptations for a piscivorous diet, or if they largely lived and foraged in aquatic habitats. The holotype of Irritator...

Université de Fribourg

Metal nanoparticle–microbe interactions: synthesis and antimicrobial effects

Khan, Mujeebur R. ; Fromm, Katharina M. ; Rizvi, Tanveer F. ; Giese, Bernd ; Ahamad, Faheem ; Turner, Raymond J. ; Füeg, Michael ; Marsili, Enrico

In: Particle & Particle Systems Characterization, 2020, vol. 37, no. 5, p. 1900419

Metal nanoparticles (NPs), chalcogenides, and carbon quantum dots can be easily synthesized from whole microorganisms (fungi and bacteria) and cell‐free sterile filtered spent medium. The particle size distribution and the biosynthesis time can be somewhat controlled through the biomass/metal solution ratio. The biosynthetic mechanism can be explained through the ion‐reduction theory and...

Université de Fribourg

Metal nanoparticle–microbe interactions: synthesis and antimicrobial effects

Khan, Mujeebur R. ; Fromm, Katharina M. ; Rizvi, Tanveer F. ; Giese, Bernd ; Ahamad, Faheem ; Turner, Raymond J. ; Füeg, Michael ; Marsili, Enrico

In: Particle & Particle Systems Characterization, 2020, vol. 37, no. 5, p. 1900419

Metal nanoparticles (NPs), chalcogenides, and carbon quantum dots can be easily synthesized from whole microorganisms (fungi and bacteria) and cell‐free sterile filtered spent medium. The particle size distribution and the biosynthesis time can be somewhat controlled through the biomass/metal solution ratio. The biosynthetic mechanism can be explained through the ion‐reduction theory and...

Università della Svizzera italiana

Explaining the microtubule energy balance : contributions due to dipole moments, charges, van der Waals and solvation energy

Ayoub, Ahmed Taha ; Staelens, Michael ; Prunotto, Alessio ; Deriu, Marco A. ; Danani, Andrea ; Klobukowski, Mariusz ; Tuszynski, Jack Adam

In: International journal of molecular sciences, 2017, vol. 18, no. 10, p. 2042

Microtubules are the main components of mitotic spindles, and are the pillars of the cellular cytoskeleton. They perform most of their cellular functions by virtue of their unique dynamic instability processes which alternate between polymerization and depolymerization phases. This in turn is driven by a precise balance between attraction and repulsion forces between the constituents of...

Università della Svizzera italiana

Insights into the effect of the G245S single point mutation on the structure of p53 and the binding of the protein to DNA

Lepre, Marco Gaetano ; Omar, Sara Ibrahim ; Grasso, Gianvito ; Morbiducci, Umberto ; Deriu, Marco Agostino ; Tuszynski, Jack A.

In: Molecules, 2017, vol. 22, no. 8, p. 1358

The transcription factor p53 is a potent tumor suppressor dubbed as the “guardian of the genome” because of its ability to orchestrate protective biological outputs in response to a variety of oncogenic stresses. Mutation and thus inactivation of p53 can be found in 50% of human tumors. The majority are missense mutations located in the DNA binding region. Among them, G245S is known to be...

Università della Svizzera italiana

A novel interaction between the TLR7 and a colchicine derivative revealed through a computational and experimental study

Gentile, Francesco ; Deriu, Marco A. ; Barakat, Khaled ; Danani, Andrea ; Tuszynski, Jack

In: Pharmaceuticals, 2018, vol. 11, no. 1, p. 22

The Toll-Like Receptor 7 (TLR7) is an endosomal membrane receptor involved in the innate immune system response. Its best-known small molecule activators are imidazoquinoline derivatives such as imiquimod (R-837) and resiquimod (R-848). Recently, an interaction between R-837 and the colchicine binding site of tubulin was reported. To investigate the possibility of an interaction between...

Consortium of Swiss Academic Libraries

Changing Face of Vaccination in Immunocompromised Hosts

O'Shea, Daire ; Widmer, Lukas ; Stelling, Jörg ; Egli, Adrian

In: Current Infectious Disease Reports, 2014, vol. 16, no. 9, p. 1-11