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Université de Fribourg

A novel study on the inhibitory effect of marine macroalgal extracts on hyphal growth and biofilm formation of candidemia isolates

El-Zawawy, Nessma A. ; El-Shenody, Rania A. ; Ali, Sameh S. ; El-Shetehy, Mohamed

In: Scientific Reports, 2020, vol. 10, no. 1, p. 9339

Biofilm formation and hyphal growth are considered to be the most serious virulence factors of Candida species in blood causing candidemia infections, which are difficult to treat due to the spread of resistant Candida isolates to most antifungal drugs. Therefore, in this study, we investigated the effect of different types and concentrations of selected macroalgal extracts from Cladostephus...

Université de Fribourg

Use of EpiAlveolar lung model to predict fibrotic potential of multiwalled carbon nanotubes

Barosova, Hana ; Maione, Anna G. ; Septiadi, Dedy ; Sharma, Monita ; Haeni, Laetitia ; Balog, Sandor ; O’Connell, Olivia ; Jackson, George R. ; Brown, David ; Clippinger, Amy J. ; Hayden, Patrick ; Petri-Fink, Alke ; Stone, Vicki ; Rothen-Rutishauser, Barbara

In: ACS Nano, 2020, vol. 14, no. 4, p. 3941–3956

Expansion in production and commercial use of nanomaterials increases the potential human exposure during the lifecycle of these materials (production, use, and disposal). Inhalation is a primary route of exposure to nanomaterials; therefore it is critical to assess their potential respiratory hazard. Herein, we developed a three-dimensional alveolar model (EpiAlveolar) consisting of human...

Université de Fribourg

Antimicrobial effects of antipyretics

Zimmermann, Petra ; Curtis, Nigel

In: Antimicrobial Agents and Chemotherapy, 2017, vol. 61, no. 4, p. -

Antipyretics are some of the most commonly used drugs. Since they are often coadministered with antimicrobial therapy, it is important to understand the interactions between these two classes of drugs. Our review is the first to summarize the antimicrobial effects of antipyretic drugs and the underlying mechanisms involved. Antipyretics can inhibit virus replication, inhibit or promote...

Université de Fribourg

The effects of temperature and dispersal on species diversity in natural microbial metacommunities

Parain, Elodie C. ; Gray, Sarah M. ; Bersier, Louis-Félix

In: Scientific Reports, 2019, vol. 9, no. 1, p. 18286

Dispersal is key for maintaining biodiversity at local- and regional scales in metacommunities. However, little is known about the combined effects of dispersal and climate change on biodiversity. Theory predicts that alpha-diversity is maximized at intermediate dispersal rates, resulting in a hump-shaped diversity-dispersal relationship. This relationship is predicted to flatten when...

Université de Fribourg

Catheter-related infections: does the spectrum of microbial causes change over time? A nationwide surveillance study

Buetti, Niccolò ; Priore, Elia Lo ; Atkinson, Andrew ; Widmer, Andreas F ; Kronenberg, Andreas ; Marschall, Jonas ; Swiss Centre for Antibiotic Resistance (ANRESIS)

In: BMJ Open, 2018, vol. 8, no. 12, p. e023824

Objectives To estimate the incidence and epidemiology of catheter-related bloodstream infections (CRBSIs) on a national scale by using prospective epidemiological data from the Swiss Antibiotic Resistance Surveillance System (ANRESIS). Design Observational study. Setting National surveillance from 2008 to 2015 of acute hospitals in Switzerland. Participants We included acute Swiss hospitals...

Consortium of Swiss Academic Libraries

Biofilm engineering: linking biofilm development at different length and time scales

Morgenroth, E. ; Milferstedt, K.

In: Reviews in Environmental Science and Bio/Technology, 2009, vol. 8, no. 3, p. 203-208