Affiner les résultats

Langue

Université de Fribourg

New paroxyclaenid mammals from the early Eocene of the Paris Basin (France) shed light on the origin and evolution of these endemic European cimolestans

Solé, Floréal ; Plateau, Olivia ; Le Verger, Kévin ; Phélizon, Alain

In: Journal of Systematic Palaeontology, 2019, vol. 17, no. 20, p. 1711–1743

We present new species of an enigmatic family of mammals, which is endemic to Europe, the Paroxyclaenidae: Merialus bruneti sp. nov., Fratrodon tresvauxi gen. et sp. nov., Paraspaniella gunnelli gen. et sp. nov., and Sororodon tresvauxae gen. et sp. nov. The fossils described come from six localities of the Ypresian of the Paris Basin (France): Pourcy (MP7), Mutigny, Avenay, Condé-en-Brie...

Université de Fribourg

Early Agenian rhinocerotids from Wischberg (Canton Bern, Switzerland) and clarification of the systematics of the genus Diaceratherium

Jame​, Claire ; Tissier​​, Jérémy ; Maridet, Olivier ; Becker, Damien

In: PeerJ, 2019, vol. 7, p. e7517

Background: Wischberg is a Swiss locality in Bern Canton which has yielded numerous vertebrates remains from the earliest Miocene (= MN1). It has a very rich faunal diversity, one of the richest in Switzerland for this age. Among all the mammals reported in the original faunal list 70 years ago, three rhinocerotid species were identified. The material consists of two fragmentary skulls,...

Université de Fribourg

Multilayered control of protein turnover by torc1 and atg1

Hu, Zehan ; Raucci, Serena ; Jaquenoud, Malika ; Hatakeyama, Riko ; Stumpe, Michael ; Rohr, Rudolf ; Reggiori, Fulvio ; Virgilio, Claudio De ; Dengjel, Jörn

In: Cell Reports, 2019, vol. 28, no. 13, p. 3486-3496.e6

The target of rapamycin complex 1 (TORC1) is a master regulator of cell homeostasis, which promotes anabolic reactions and synchronously inhibits catabolic processes such as autophagy-mediated protein degradation. Its prime autophagy target is Atg13, a subunit of the Atg1 kinase complex that acts as the gatekeeper of canonical autophagy. To study whether the activities of TORC1 and Atg1 are...

Université de Fribourg

Northern Hemisphere permafrost map based on TTOP modelling for 2000–2016 at 1 km2 scale

Obu, Jaroslav ; Westermann, Sebastian ; Bartsch, Annett ; Berdnikov, Nikolai ; Christiansen, Hanne H. ; Dashtseren, Avirmed ; Delaloye, Reynald ; Elberling, Bo ; Etzelmüller, Bernd ; Kholodov, Alexander ; Khomutov, Artem ; Kääb, Andreas ; Leibman, Marina O. ; Lewkowicz, Antoni G. ; Panda, Santosh K. ; Romanovskyh, Vladimir ; Wayk, Robert G. ; Westergaard-Nielsen, Andreas ; Wu, Tonghua ; Yamkhin, Jambaljav ; Zou, Defu

In: Earth-Science Reviews, 2019, vol. 193, p. 299–316

Permafrost is a key element of the cryosphere and an essential climate variable in the Global Climate Observing System. There is no remote-sensing method available to reliably monitor the permafrost thermal state. To estimate permafrost distribution at a hemispheric scale, we employ an equilibrium state model for the temperature at the top of the permafrost (TTOP model) for the 2000–2016...

Università della Svizzera italiana

Endoplasmic reticulum turnover : ER-phagy and other flavors in selective and non-selective ER clearance

Fregno, Ilaria ; Molinari, Maurizio

In: F1000Research, 2018, vol. 7, p. 454

The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells. It is deputed to lipid and protein biosynthesis, calcium storage, and the detoxification of various exogenous and endogenous harmful compounds. ER activity and size must be adapted rapidly to environmental and developmental conditions or biosynthetic demand. This is achieved on induction of thoroughly studied...

Université de Fribourg

Reduced skeletal muscle protein turnover and thyroid hormone metabolism in adaptive thermogenesis that facilitates body fat recovery during weight regain

Calonne, Julie ; Isacco, Laurie ; Miles-Chan, Jennifer L. ; Arsenijevic, Denis ; Montani, Jean-Pierre ; Guillet, Christelle ; Boirie, Yves ; Dulloo, Abdul G.

In: Frontiers in Endocrinology, 2019, vol. 10, p. -

Objective: The recovery of body composition after weight loss is characterized by an accelerated rate of fat recovery (preferential catch-up fat) resulting partly from an adaptive suppression of thermogenesis. Although the skeletal muscle has been implicated as an effector site for such thrifty (energy conservation) metabolism driving catch-up fat, the underlying mechanisms remain to be...

Université de Fribourg

Biochronological and palaeobiogeographical significance of the earliest Miocene mammal fauna from Northern Vietnam

Antoine, Pierre-Olivier ; Made, Jan van der ; Métais, Grégoire ; Phuc, Laq The ; Quan, Quý Tr??ng ; Schneider, Simon ; Tran, Dang Ngoc ; Vasilyan, Davit ; Viet, Luong The ; Böhme, Madelaine

In: Palaeobiodiversity and Palaeoenvironments, 2018, vol. 98, no. 2, p. 287–313

Current scientific knowledge of Tertiary fossils from south of the Ailao Shan-Red River shear zone is extremely poor, in sharp contrast with the situation nowadays, as the area of Laos and Vietnam is regarded as a global hotspot of biodiversity. In this context, the few localities that yielded fossil assemblages are of first importance for the understanding of Cenozoic palaeobiogeography and...