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Université de Fribourg

Single cell transcriptome atlas of the Drosophila larval brain

Brunet Avalos, Clarisse ; Maier, G. Larisa ; Bruggmann, Rémy ; Sprecher, Simon G.

In: eLife, 2019, vol. 8, p. e50354

Cell diversity of the brain and how it is affected by starvation, remains largely unknown. Here, we introduce a single cell transcriptome atlas of the entire Drosophila first instar larval brain. We first assigned cell-type identity based on known marker genes, distinguishing five major groups: neural progenitors, differentiated neurons, glia, undifferentiated neurons and non-neural cells....

Université de Fribourg

Structural brain differences predict early traumatic memory processing

Gvozdanovic, Geraldine ; Stämpfli, Philipp ; Seifritz, Erich ; Rasch, Björn

In: Psychophysiology, 2019, no. Special Issue: "The psychophysiology of trauma exposure", p. 1-11

Université de Fribourg

Balance training reduces brain activity during motor simulation of a challenging balance task in older adults: an fMRI study

Ruffieux, Jan ; Mouthon, Audrey ; Keller, Martin ; Mouthon, Michaël ; Annoni, Jean-Marie ; Taube, Wolfgang

In: Frontiers in Behavioral Neuroscience, 2018, vol. 12, p. -

Aging is associated with a shift from an automatic to a more cortical postural control strategy, which goes along with deteriorations in postural stability. Although balance training has been shown to effectively counteract these behavioral deteriorations, little is known about the effect of balance training on brain activity during postural tasks in older adults. We, therefore, assessed...

Université de Fribourg

Super resolution imaging of genetically labeled synapses in drosophila brain tissue

Spühler, Isabelle A. ; Conley, Gaurasundar M. ; Scheffold, Frank ; Sprecher, Simon G.

In: Frontiers in Cellular Neuroscience, 2016, p. 142

Understanding synaptic connectivity and plasticity within brain circuits and their relationship to learning and behavior is a fundamental quest in neuroscience. Visualizing the fine details of synapses using optical microscopy remains however a major technical challenge. Super resolution microscopy opens the possibility to reveal molecular features of synapses beyond the diffraction limit....

Université de Fribourg

Notch signaling in the brain: In good and bad times

Alberi, Lavinia ; Hoey, Sarah ; Brai, Emanuele ; Scotti, Alessandra ; Marathe, Swananda

In: Ageing Research Reviews, 2013, p. -

Notch signaling is an evolutionarily conserved pathway, which is fundamental for neuronal development and specification. In the last decade, increasing evidence has pointed out an important role of this pathway beyond embryonic development, indicating that Notch also displays a critical function in the mature brain of vertebrates and invertebrates. This pathway appears to be involved in neural...