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Université de Fribourg

The Eomyidae in Asia: Biogeography, diversity and dispersals

Kimura, Yuri ; Casanovas-Vilar, Isaac ; Maridet, Olivier ; Kalthoff, Daniela C. ; Mörs, Thomas ; Tomida, Yukimitsu

In: Fossil Imprint, 2020, vol. 76, no. 1, p. 181-200

In Asia, the first find of an eomyid rodent was reported almost one century after the first studies of the family Eomyidae in North America and Europe. Since then, eomyid rodents have been increasingly found in Asia particularly over the past two decades. Here, we review the Asian record of this family at the genus level. Currently, 22 species within 14 genera were reported from Asia,...

Université de Fribourg

The role of TNFR2 and DR3 in the in vivo expansion of tregs in T cell depleting transplantation regimens

Rodriguez-Barbosa, Jose-Ignacio ; Schneider, Pascal ; Graca, Luis ; Bühler, Leo ; Perez-Simon, Jose-Antonio ; Rio, Maria-Luisa del

In: International Journal of Molecular Sciences, 2020, vol. 21, no. 9, p. 3347

Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to promote...

Université de Fribourg

The last surviving Thalassochelydia — A new turtle cranium from the Early Cretaceous of the Purbeck Group (Dorset, UK)

Anquetin, Jérémy ; André, Charlotte

In: PaleorXiv, 2020, p. 7pa5c

Background. The mostly Berriasian (Early Cretaceous) Purbeck Group of southern England has produced a rich turtle fauna dominated by the freshwater paracryptodires Pleurosternon bullockii and Dorsetochelys typocardium. Each of these species is known by numerous relatively complete shells and by a single cranium. The two other turtles found in the Purbeck Group (Hylaeochelys belli, a species of...

Université de Fribourg

Effects of anti-PD-1 immunotherapy on tumor regression: insights from a patient-derived xenograft model

Martín-Ruiz, Asunción ; Fiuza-Luces, Carmen ; Martínez-Martínez, Esther ; Arias, Clemente F. ; Gutiérrez, Lourdes ; Ramírez, Manuel ; Martín-Acosta, Paloma ; Coronado, Maria José ; Lucia, Alejandro ; Provencio, Mariano

In: Scientific Reports, 2020, vol. 10, no. 1, p. 7078

Immunotherapies, such as checkpoint blockade of programmed cell death protein-1 (PD-1), have resulted in unprecedented improvements in survival for patients with lung cancer. Nonetheless, not all patients benefit equally and many issues remain unresolved, including the mechanisms of action and the possible effector function of immune cells from non-lymphoid lineages. The purpose of this...

Université de Fribourg

A new species of baenid turtle from the Early Cretaceous Lakota Formation of South Dakota

Joyce, Walter G. ; Rollot, Yann ; Cifelli, Richard L.

In: Fossil Record, 2020, vol. 23, no. 1, p. 1–13

Baenidae is a clade of paracryptodiran turtles known from the late Early Cretaceous to Eocene of North America. The proposed sister-group relationship of Baenidae to Pleurosternidae, a group of turtles known from sediments dated as early as the Late Jurassic, suggests a ghost lineage that crosses the early Early Cretaceous. We here document a new species of paracryptodiran turtle, Lakotemys...

Università della Svizzera italiana

An MVA vector expressing HIV-1 envelope under the control of a potent vaccinia virus promoter as a promising strategy in HIV/AIDS vaccine design

Pérez, Patricia ; Marín, María Q. ; Lázaro-Frías, Adrián ; Sorzano, Carlos Óscar S. ; Di Pilato, Mauro ; Gómez, Carmen E. ; Esteban, Mariano ; García-Arriaza, Juan

In: Vaccines, 2019, vol. 7, no. 4, p. 208

Highly attenuated poxviral vectors, such as modified vaccinia virus ankara (MVA), are promising vaccine candidates against several infectious diseases. One of the approaches developed to enhance the immunogenicity of poxvirus vectors is increasing the promoter strength and accelerating during infection production levels of heterologous antigens. Here, we have generated and characterized the ...

Université de Fribourg

The last Palaeoproteus (Urodela: Batrachosauroididae) of Europe

Vasilyan, Davit ; Yanenko, Vadym

In: Scientific Reports, 2020, vol. 10, p. 2733

The Batrachosauroididae are an enigmatic group of salamanders known from the Cretaceous and Tertiary of North America and Europe. In Europe, the family is known only by two species of the genus Palaeoproteus. The genus has limited distribution in Western and Central Europe. In the present paper, we describe a new species, Palaeoproteus miocenicus, from the early late Miocene (11–9 Ma) of...