In: Evolutionary Biology, 2015, vol. 42, no. 1, p. 1-11
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In: bioRxiv, 2021, p. 244061
The Miocene sands of the Swiss Jura Mountains, long exploited in quarries for the construction industry, have yielded abundant fossil remains of large mammals. Among Deinotheriidae (Proboscidea), two species, Prodeinotherium bavaricum and Deinotherium giganteum, had previously been identified in the Delémont valley, but never described. A third species, Deinotherium levius, from the locality of...
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In: Proceedings of the National Academy of Sciences, 2020, vol. 117, no. 46, p. 28867–28875
Competition among species and entire clades can impact species diversification and extinction, which can shape macroevolutionary patterns. The fossil record shows successive biotic turnovers such that a dominant group is replaced by another. One striking example involves the decline of gymnosperms and the rapid diversification and ecological dominance of angiosperms in the Cretaceous. It is...
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In: Proceedings of the National Academy of Sciences, 2020, vol. 117, no. 42, p. 26281–26287
The biological interchange between North and South America associated with the formation of the Isthmus of Panama is key to defining current gradients of species diversity. A major gap in our understanding of the interchange is its asymmetry, where mammals of North American origin attained higher diversity in South America than vice versa. The prevailing view is that this asymmetry resulted...
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In: Ecosphere, 2020, vol. 11, no. 2, p. -
In search of generalities in biological invasions, it is sometimes forgotten that invader success can be a function of both the diversity of the invaded community and the relatedness of the invader relative to community residents. Both qualities are likely to be especially important in stressful ecosystems, and identifying the species and community attributes that influence biological ...
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In: International journal of molecular sciences, 2017, vol. 18, no. 10, p. 2042
Microtubules are the main components of mitotic spindles, and are the pillars of the cellular cytoskeleton. They perform most of their cellular functions by virtue of their unique dynamic instability processes which alternate between polymerization and depolymerization phases. This in turn is driven by a precise balance between attraction and repulsion forces between the constituents of...
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In: Molecules, 2017, vol. 22, no. 8, p. 1358
The transcription factor p53 is a potent tumor suppressor dubbed as the “guardian of the genome” because of its ability to orchestrate protective biological outputs in response to a variety of oncogenic stresses. Mutation and thus inactivation of p53 can be found in 50% of human tumors. The majority are missense mutations located in the DNA binding region. Among them, G245S is known to be...
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In: Pharmaceuticals, 2018, vol. 11, no. 1, p. 22
The Toll-Like Receptor 7 (TLR7) is an endosomal membrane receptor involved in the innate immune system response. Its best-known small molecule activators are imidazoquinoline derivatives such as imiquimod (R-837) and resiquimod (R-848). Recently, an interaction between R-837 and the colchicine binding site of tubulin was reported. To investigate the possibility of an interaction between...
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In: Bulletin of the Peabody Museum of Natural History, 2019, vol. 60, no. 2, p. 129–155
The fossil record of nonbaenid paracryptodires ranges from the Late Jurassic (Kimmeridgian) to the Paleocene of North America and Europe only. Earlier remains may be present as early as the Middle Jurassic (Bathonian). Only a single dispersal event is documented between the two continents after their breakup during the Cretaceous in the form of the appearance of the Compsemys lineage in the ...
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In: Ex-Voto. Votive Giving Across Cultures, 2016, p. 76-105
Ex-voto; Art médiéval;
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