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Université de Fribourg

Screening for Intestinal Carriage of Extended-spectrum Beta-lactamase–producing Enterobacteriaceae in Critically Ill Patients: Expected Benefits and Evidence-based Controversies

Zahar, Jean-Ralph ; Blot, Stijn ; Nordmann, Patrice ; Martischang, Romain ; Timsit, Jean-François ; Harbarth, Stephan ; Barbier, François

In: Clinical Infectious Diseases, 2018, p. -

The rising burden of intensive care unit (ICU)-acquired infections due to extended- spectrum beta-lactamase–producing Enterobacteriaceae (ESBL-E) strengthens the requirement for efficient prevention strategies. The detection of intestinal carriage of ESBL-E through active surveillance cultures (ASC) and the implementation of contact precautions (CP) in carriers are currently advocated in...

Université de Fribourg

Catheter-related infections: does the spectrum of microbial causes change over time? A nationwide surveillance study

Buetti, Niccolò ; Priore, Elia Lo ; Atkinson, Andrew ; Widmer, Andreas F ; Kronenberg, Andreas ; Marschall, Jonas ; Swiss Centre for Antibiotic Resistance (ANRESIS)

In: BMJ Open, 2018, vol. 8, no. 12, p. e023824

Objectives To estimate the incidence and epidemiology of catheter-related bloodstream infections (CRBSIs) on a national scale by using prospective epidemiological data from the Swiss Antibiotic Resistance Surveillance System (ANRESIS). Design Observational study. Setting National surveillance from 2008 to 2015 of acute hospitals in Switzerland. Participants We included acute Swiss hospitals...

Université de Fribourg

How do the global stock markets influence one another? Evidence from finance big data and Granger causality directed network

Tang, Yong ; Xiong, Jason Jie ; Luo, Yong ; Zhang, Yi-Cheng

In: International Journal of Electronic Commerce, 2019, vol. 23, no. 1, p. 85–109

The recent financial network analysis approach reveals that the topologies of financial markets have an important influence on market dynamics. However, the majority of existing Finance Big Data networks are built as undirected networks without information on the influence directions among prices. Rather than understanding the correlations, this research applies the Granger causality test to...

Université de Fribourg

Comparative study of nonequilibrium insulator-to-metal transitions in electron-phonon systems

Sayyad, Sharareh ; Žitko, Rok ; Strand, Hugo U. R. ; Werner, Philipp ; Golež, Denis

In: Physical Review B, 2019, vol. 99, no. 4, p. 045118

We study equilibrium and nonequilibrium properties of electron-phonon systems described by the Hubbard-Holstein model using dynamical mean-field theory. In equilibrium, we benchmark the results for impurity solvers based on the one-crossing approximation and slave-rotor approximation against non-perturbative numerical renormalization group reference data. We also examine how well the...

Université de Fribourg

Particle-conserving dynamics on the single-particle level

Schindler, T. ; Wittmann, René ; Brader, Joseph M.

In: Physical Review E, 2019, vol. 99, no. 1, p. 012605

We generalize the particle-conserving dynamics method of de las Heras et al. [J. Phys.: Condens. Matter 28, 244024 (2016)] to binary mixtures and apply this to hard rods in one dimension. Considering the case of one species consisting of only one particle enables us to address the tagged-particle dynamics. The time-evolution of the species-labeled density profiles is compared to exact...

Université de Fribourg

Fluid demixing kinetics on spherical geometry: power spectrum and Minkowski functional analysis

Böbel, A ; Bott, Matthias Christian ; Modest, H ; Brader, Joseph M. ; Räth, C

In: New Journal of Physics, 2019, vol. 21, no. 1, p. 013031

Dynamic density functional theory calculations of fluid–fluid demixing on spherical geometries are characterized via their angular power spectrum as well as via the Minkowski functionals (MFs) of their binarized fluid density fields. MFs form a complete set of additive, motion invariant and continuous morphological measures sensitive to nonlinear (spatial) correlations. The temporal...

Accès public à partir du 30 janv. 2020
Università della Svizzera italiana

The contribution of active and passive mechanisms of 5mC and 5hmC removal in human T lymphocytes is differentiation- and activation-dependent

Vincenzetti, Lucia ; Leoni, Cristina ; Chirichella, Michele ; Kwee, Ivo ; Monticelli, Silvia

In: European Journal of Immunology, 2019, p. 1-15

In mammals, the 5’-methylcytosine (5mC) modification in the genomic DNA contributes to the dynamic control of gene expression. 5mC erasure is required for the activation of developmental programs and occurs either by passive dilution through DNA replication, or by enzymatic oxidation of the methyl mark to 5-hydroxymethylcytosine (5hmC), which can persist as such or undergo further oxidation...

Université de Fribourg

T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field

Sanz‑Ortega, Laura ; Rojas, José M. ; Marcos, Ana ; Portilla, Yadileiny ; Stein, Jens V. ; Barber, Domingo F.

In: Journal of Nanobiotechnology, 2019, vol. 17, no. 1, p. 14

T lymphocytes are highly dynamic elements of the immune system with a tightly regulated migration. T cell-based transfer therapies are promising therapeutic approaches which in vivo efficacy is often limited by the small proportion of administered cells that reaches the region of interest. Manipulating T cell localisation to improve specific targeting will increase the effectiveness of these...

Université de Fribourg

Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation

Mottas, Inès ; Bekdemir, Ahmet ; Cereghetti, Alessandra ; Spagnuolo, Lorenzo ; Yang, Yu-Sang Sabrina ; Müller, Marie ; J.Irvine, Darrell ; Stellaccic, Francesco ; Bourquin, Carole

In: Biomaterials, 2019, vol. 190–191, p. 111–120

Although immunotherapy shows great promise for the long-term control of cancer, many tumors still fail to respond to treatment. To improve the outcome, the delivery of immunostimulants to the lymph nodes draining the tumor, where the antitumor immune response is initiated, is key. Efforts to use nanoparticles as carriers for cancer immunotherapy have generally required targeting agents and...

Université de Fribourg

The diffeomorphism type of small hyperplane arrangements is combinatorially determined

Gallet, Matteo ; Saini, Elia

In: Advances in Geometry, 2019, vol. 19, no. 1, p. 89–100

It is known that there exist hyperplane arrangements with the same underlying matroid that admit non-homotopy equivalent complement manifolds. Here we show that, in any rank, complex central hyperplane arrangements with up to 7 hyperplanes and the same underlying matroid are isotopic. In particular, the diffeomorphism type of the complement manifold and the Milnor fiber and fibration of these...