Affiner les résultats

TAT-RasGAP317-326-mediated tumor cell death sensitization can occur independently of Bax and Bak

Annibaldi, Alessandro ; Heulot, Mathieu ; Martinou, Jean-Claude ; Widmann, Christian

In: Apoptosis, 2014, vol. 19, no. 4, p. 719-733

Templated assembly of pore-forming peptides in lipid membranes

Fennouri, Aziz ; List, Jonathan ; Dupasquier, Jessica ; Haeni, Laetitia ; Vanni, Stefano ; Rothen-Rutishauser, Barbara ; Mayer, Michael

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 59–62

Pore-forming peptides are of interest due to their antimicrobial activity and ability to form gateways through lipid membranes. Chemical modification of these peptides makes it possible to arrange several peptide monomers into well-defined pore-forming structures using various templating strategies. These templated super-structures can exert antimicrobial activity at significantly lower total...

Membrane protein dynamics in different environments: simulation study of the outer membrane protein X in a lipid bilayer and in a micelle

Choutko, Alexandra ; Glättli, Alice ; Fernández, César ; Hilty, Christian ; Wüthrich, Kurt ; van Gunsteren, Wilfred

In: European Biophysics Journal, 2011, vol. 40, no. 1, p. 39-58

The bisphosphonate zoledronic acid inhibits the growth of HCT-116 colon carcinoma cells and induces tumor cell apoptosis

Sewing, Lilian ; Steinberg, Florian ; Schmidt, Harald ; Göke, Rüdiger

In: Apoptosis, 2008, vol. 13, no. 6, p. 782-789

A Quantitative Approach to Membrane Binding of Human Ubiquitous Mitochondrial Creatine Kinase Using Surface Plasmon Resonance

Schlattner, Uwe ; Wallimann, Theo

In: Journal of Bioenergetics and Biomembranes, 2000, vol. 32, no. 1, p. 123-131

Implications of Bid Design and Willingness-To-Pay Distribution for Starting Point Bias in Double-Bounded Dichotomous Choice Contingent Valuation Surveys

Veronesi, Marcella ; Alberini, Anna ; Cooper, Joseph

In: Environmental and Resource Economics, 2011, vol. 49, no. 2, p. 199-215

Perceptions and behaviours of infectious diseases physicians when managing urinary tract infections due to MDR organisms

Trevino, Sergio E. ; Babcock, Hilary M. ; Henderson, Jeffrey P. ; Lane, Michael A. ; Beekmann, Susan E. ; Polgreen, Philip M. ; Marschall, Jonas

In: Journal of Antimicrobial Chemotherapy, 2015, vol. 70, no. 12, p. 3397-3400

Granzyme B-induced mitochondrial ROS are required for apoptosis

Jacquemin, G. ; Margiotta, D. ; Kasahara, A. ; Bassoy, E. Y. ; Walch, Michael ; Thiery, J. ; Lieberman, J. ; Martinvalet, Denis

In: Cell Death & Differentiation, 2015, vol. 22, no. 5, p. 862–874

Caspases and the cytotoxic lymphocyte protease granzyme B (GB) induce reactive oxygen species (ROS) formation, loss of transmembrane potential and mitochondrial outer membrane permeabilization (MOMP). Whether ROS are required for GB-mediated apoptosis and how GB induces ROS is unclear. Here, we found that GB induces cell death in an ROS-dependent manner, independently of caspases and MOMP. GB...

Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation

Schafer, Blanca ; Quispe, Joel ; Choudhary, Vineet ; Chipuk, Jerry E. ; Ajero, Teddy G. ; Du, Han ; Schneiter, Roger ; Kuwana, Tomomi

In: Molecular Biology of The Cell, 2009, vol. 20, no. 8, p. 2276-2285

Mitochondrial outer membrane permeabilization (MOMP) is a critical step in apoptosis and is regulated by Bcl-2 family proteins. In vitro systems using cardiolipin-containing liposomes have demonstrated the key features of MOMP induced by Bax and cleaved Bid; however, the nature of the "pores" and how they are formed remain obscure. We found that mitochondrial outer membranes contained very little...

Bax function in the absence of mitochondria in the primitive protozoan Giardia lamblia

Hehl, Adrian B. ; Regos, Attila ; Schraner, Elisabeth ; Schneider, André

In: PLoS ONE, 2007, vol. 2, no. 5, p. e488

Bax-induced permeabilization of the mitochondrial outer membrane and release of cytochrome c are key events in apoptosis. Although Bax can compromise mitochondria in primitive unicellular organisms that lack a classical apoptotic machinery, it is still unclear if Bax alone is sufficient for this, or whether additional mitochondrial components are required. The protozoan parasite Giardia lamblia...