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DAT1 and DRD4 genes involved in key dimensions of adult ADHD

Hasler, R. ; Salzmann, A. ; Bolzan, T. ; Zimmermann, J. ; Baud, P. ; Giannakopoulos, P. ; Perroud, N.

In: Neurological Sciences, 2015, vol. 36, no. 6, p. 861-869

Addition of methylphenidate to intensive dialectical behaviour therapy for patients suffering from comorbid borderline personality disorder and ADHD: a naturalistic study

Prada, Paco ; Nicastro, Rosetta ; Zimmermann, Julien ; Hasler, Roland ; Aubry, Jean-Michel ; Perroud, Nader

In: ADHD Attention Deficit and Hyperactivity Disorders, 2015, vol. 7, no. 3, p. 199-209

Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs

Manganelli, Valeria ; Matarrese, Paola ; Antonioli, Manuela ; Gambardella, Lucrezia ; Vescovo, Tiziana ; Gretzmeier, Christine ; Longo, Agostina ; Capozzi, Antonella ; Recalchi, Serena ; Riitano, Gloria ; Misasi, Roberta ; Dengjel, Jörn ; Malorni, Walter ; Fimia, Gian Maria ; Sorice, Maurizio ; Garofalo, Tina

In: Autophagy, 2020, p. 1-21

Mitochondria-associated membranes (MAMs) are essential communication subdomains of the endoplasmic reticulum (ER) that interact with mitochondria. We previously demonstrated that, upon macroautophagy/autophagy induction, AMBRA1 is recruited to the BECN1 complex and relocalizes to MAMs, where it regulates autophagy by interacting with raft-like components. ERLIN1 is an endoplasmic reticulum...

Bovine lactoferrin-induced CCL1 expression involves distinct receptors in monocyte-derived dendritic cells and their monocyte precursors

Latorre, Daniela ; Pulvirenti, Nadia ; Covino, Daniela Angela ; Varano, Barbara ; Purificato, Cristina ; Rainaldi, Gabriella ; Gauzzi, Maria Cristina ; Fantuzzi, Laura ; Conti, Lucia ; Donninelli, Gloria ; Del Cornò, Manuela ; Sabbatucci, Michela ; Gessani, Sandra ; Puddu, Patrizia

In: Toxins, 2015, vol. 7, no. 12, p. 5472-5483

Lactoferrin (LF) exhibits a wide range of immunomodulatory activities including modulation of cytokine and chemokine secretion. In this study, we demonstrate that bovine LF (bLF) up-modulates, in a concentration- and time-dependent manner, CCL1 secretion in monocytes (Mo) at the early stage of differentiation toward dendritic cells (DCs), and in fully differentiated immature Mo-derived DCs...

Characterization of variable regions of the Gp120 protein from HIV-1 subtype C virus variants obtained from individuals at different disease stages in Sub-Saharan Africa

Cenci, A. ; Tavoschi, L. ; D'Avenio, G. ; Narino, P. ; Becattini, S. ; Bernasconi, D. ; Chiappi, M. ; La Torre, L. ; Sukati, H. ; Vardas, E. ; Lo Presti, A. ; Cella, E. ; Ciccozzi, M. ; Picconi, O. ; Monini, P. ; Ensoli, B. ; Buttò, S.

In: Journal of AIDS & clinical research, 2012, vol. S8:006, p. 1-10

Background: The development of a vaccine against HIV/AIDS capable of preventing virus infection has been hampered by the HIV envelope (Env) heterogeneity that makes it difficult to induce neutralizing antibodies against Env proteins from different HIV clades. Several studies have indicated that gp120 Env protein sequence tends to change considerably during the course of HIV disease which...

Clinical presentation and outcome in a series of 88 patients with the cblC defect

Fischer, Sabine ; Huemer, Martina ; Baumgartner, Matthias ; Deodato, Federica ; Ballhausen, Diana ; Boneh, Avihu ; Burlina, Alberto ; Cerone, Roberto ; Garcia, Paula ; Gökçay, Gülden ; Grünewald, Stephanie ; Häberle, Johannes ; Jaeken, Jaak ; Ketteridge, David ; Lindner, Martin ; Mandel, Hanna ; Martinelli, Diego ; Martins, Esmeralda ; Schwab, Karl ; Gruenert, Sarah ; Schwahn, Bernd ; Sztriha, László ; Tomaske, Maren ; Trefz, Friedrich ; Vilarinho, Laura ; Rosenblatt, David ; Fowler, Brian ; Dionisi-Vici, Carlo

In: Journal of Inherited Metabolic Disease, 2014, vol. 37, no. 5, p. 831-840

The neurobiological link between OCD and ADHD

Brem, Silvia ; Grünblatt, Edna ; Drechsler, Renate ; Riederer, Peter ; Walitza, Susanne

In: ADHD Attention Deficit and Hyperactivity Disorders, 2014, vol. 6, no. 3, p. 175-202

Ataxia, Intellectual Disability, and Ocular Apraxia with Cerebellar Cysts: A New Disease?

Poretti, Andrea ; Häusler, Martin ; von Moers, Arpad ; Baumgartner, Bastian ; Zerres, Klaus ; Klein, Andrea ; Aiello, Chiara ; Moro, Francesca ; Zanni, Ginevra ; Santorelli, Filippo ; Huisman, Thierry ; Weis, Joachim ; Valente, Enza ; Bertini, Enrico ; Boltshauser, Eugen

In: The Cerebellum, 2014, vol. 13, no. 1, p. 79-88

The concept of instability: a French perspective on the concept of ADHD

Bader, Michel ; Hadjikhani, Nouchine

In: ADHD Attention Deficit and Hyperactivity Disorders, 2014, vol. 6, no. 1, p. 11-17

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

Rita, Anthea Di ; Peschiaroli, Angelo ; D?Acunzo, Pasquale ; Strobbe, Daniela ; Hu, Zehan ; Gruber, Jens ; Nygaard, Mads ; Lambrughi, Matteo ; Melino, Gerry ; Papaleo, Elena ; Dengjel, Jörn ; Alaoui, Said El ; Campanella, Michelangelo ; Dötsch, Volker ; Rogov, Vladimir V. ; Strappazzon, Flavie ; Cecconi, Francesco

In: Nature Communications, 2018, vol. 9, no. 1, p. 3755

The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 regulator-1) has been defined as a novel regulator of mitophagy in both PINK1/PARKIN-dependent and -independent systems. Here, we identified the E3...