In: Cerebral Cortex, 2017, vol. 27, no. 9, p. 4570-4585
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In: Biology Open, 2020, vol. 9, no. 8, p. -
Environmental factors such as the availability of oxygen are instructive cues that regulate stem cell maintenance and differentiation. We used a genetically encoded biosensor to monitor the hypoxic state of neural cells in the larval brain of Drosophila. The biosensor reveals brain compartment and cell-type specific levels of hypoxia. The values correlate with differential tracheolation that...
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In: Frontiers in Ecology and Evolution, 2020, vol. 8, p. 82
Nervous systems are complex cellular structures that allow animals to interact with their environment, which includes both the external and the internal milieu. The astonishing diversity of nervous system architectures present in all animal clades has prompted the idea that selective forces must have shaped them over evolutionary time. In most cases, neurons seem to coalesce into specific ...
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In: Cell Reports, 2020, vol. 30, no. 2, p. 397-408.e4
Pain sensation and aversive behaviors entail the activation of nociceptor neurons, whose function is largely conserved across animals. The functional heterogeneity of nociceptors and ethical concerns are challenges for their study in mammalian models. Here, we investigate the function of a single type of genetically identified C. elegans thermonociceptor named FLP. Using calcium imaging in...
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In: eLife, 2019, vol. 8, p. e50354
Cell diversity of the brain and how it is affected by starvation, remains largely unknown. Here, we introduce a single cell transcriptome atlas of the entire Drosophila first instar larval brain. We first assigned cell-type identity based on known marker genes, distinguishing five major groups: neural progenitors, differentiated neurons, glia, undifferentiated neurons and non-neural cells....
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In: Journal of Biosciences, 2014, vol. 39, no. 4, p. 595-603
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In: The Handbook of the Biology of Aging, 2006, p. 415-448
This chapter reviews hormonal effects on aging in Drosophila melanogaster. The insect juvenile hormone (JH) is a sesquiterpenoid compound produced by the corpora allata (CA), a pair of endocrine glands with nervous connections to the brain. In pre- adult development and metamorphosis, JH functions as a "status quo" hormone, allowing continued growth after ecdysteroid-induced molting....
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In: Frontiers in Behavioral Neuroscience, 2018, vol. 12, p. -
Some animals are attracted by sun light, others are highly repulsed by it. Especially for slowly moving animals, such as Drosophila larvae, direct sunlight may be perceived as noxious stimulus as it increases the risk of desiccation, DNA-damaging by UV-light and exposure to predators. For several reasons, model organisms like Drosophila larvae are well-suited for investigating how light cues...
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In: Neural Development, 2018, vol. 13, no. 1, p. 25
Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cells progress through two transient progenitor states, PI and PII, before transforming into neuroblasts. Here we analyse the role of Notch signalling in the transition from neuroepithelial...
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In: Scientific Reports, 2018, vol. 8, no. 1, p. 11272
Organisms use environmental cues for directed navigation. Understanding the basic logic behind navigational decisions critically depends on the complexity of the nervous system. Due to the comparably simple organization of the nervous system of the fruit fly larva, it stands as a powerful model to study decision-making processes that underlie directed navigation. We have quantitatively...
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