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Shared neural basis of social and non-social reward deficits in chronic cocaine users

Tobler, Philippe N. ; Preller, Katrin H. ; Campbell-Meiklejohn, Daniel K. ; Kirschner, Matthias ; Kraehenmann, Rainer ; Stämpfli, Philipp ; Herdener, Marcus ; Seifritz, Erich ; Quednow, Boris B.

In: Social Cognitive and Affective Neuroscience, 2016, vol. 11, no. 6, p. 1017-1025

Reduced volume of the nucleus accumbens in heroin addiction

Seifert, Christian ; Magon, Stefano ; Sprenger, Till ; Lang, Undine ; Huber, Christian ; Denier, Niklaus ; Vogel, Marc ; Schmidt, André ; Radue, Ernst-Wilhelm ; Borgwardt, Stefan ; Walter, Marc

In: European Archives of Psychiatry and Clinical Neuroscience, 2015, vol. 265, no. 8, p. 637-645

Physical pain recruits the nucleus accumbens during social distress in borderline personality disorder

Olié, Emilie ; Doell, Kimberly C. ; Corradi-Dell'Acqua, Corrado ; Courtet, Philippe ; Perroud, Nader ; Schwartz, Sophie

In: Social Cognitive and Affective Neuroscience, 2018, vol. 13, no. 10, p. 1071-1080

Gene expression analysis in the mouse brainstem identifies Cart and Nesfatin as neuropeptides coexpressed in the Calbindin-positive neurons of the Nucleus papilio

Girard, Franck ; von Siebenthal, Michelle ; Davis, Fred P. ; Celio, Marco R.

In: Sleep, 2020, vol. 43, no. 2020-11, p. zsaa085

Study Objectives: The brainstem contains several neuronal populations, heterogeneous in terms of neurotransmitter/neuropeptide content, which are important for controlling various aspects of the rapid eye movement (REM) phase of sleep. Among these populations are the Calbindin (Calb)-immunoreactive NPCalb neurons, located in the Nucleus papilio, within the dorsal paragigantocellular nucleus...

Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor

Bahi, Amine ; Dreyer, Jean-Luc

In: European Neuropsychopharmacology, 2020, vol. 37, p. 70–81

Recent studies have shown that Lethal-7 (let-7) microRNA (miRNA) is involved in a wide range of psychiatric disorders such as anxiety, depression, schizophrenia, and cocaine addiction. However, the exact role of let-7d miRNA in regulating ethanol intake and preference remains to be elucidated. The aim of the present study was to clarify the role of accumbal let-7d in controlling...

Striatal reactivity to reward under threat-of-shock and working memory load in adults at increased familial risk for major depression: A preliminary study

Gaillard, Claudie ; Guillod, Matthias ; Ernst, Monique ; Federspiel, Andrea ; Schoebi, Dominik ; Recabarren, Romina Evelyn ; Ouyang, Xinyi ; Mueller-Pfeiffer, Christoph ; Horschg, Antje ; Homan, Philipp ; Wiest, Roland ; Hasler, Gregor ; Martin-Soelch, Chantal

In: NeuroImage: Clinical, 2020, vol. 26, p. 102193

Introduction: Anhedonia, a core symptom of Major Depressive Disorder (MDD), manifests as a lack or loss of motivation as reflected by decreased reward responsiveness, at both behavioral and neural (i.e., striatum) levels. Exposure to stressful life events is another important risk factor for MDD. However, the mechanisms linking reward-deficit and stress to MDD remain poorly understood. Here,...

Striatal responsiveness to reward under threat‐of‐shock and working memory load : A preliminary study

Gaillard, Claudie ; Guillod, Matthias ; Ernst, Monique ; Torrisi, Salvatore ; Federspiel, Andrea ; Schoebi, Dominik ; Recabarren, Romina E. ; Ouyang, Xinyi ; Mueller-Pfeiffer, Christoph ; Horsch, Antje ; Homan, Philipp ; Wiest, Roland ; Hasler, Gregor ; Martin-Soelch, Chantal

In: Brain and Behavior, 2019, no. 9, p. 1-21

Introduction: Reward and stress are important determinants of motivated behaviors. Striatal regions play a crucial role in both motivation and hedonic processes. So far, little is known on how cognitive effort interacts with stress to modulate reward processes. This study examines how cognitive effort (load) interacts with an unpredictable acute stressor (threat-of-shock) to modulate motivational...

P2Y2 receptor activation inhibits the expression of the sodium-chloride cotransporter NCC in distal convoluted tubule cells

Gailly, P. ; Szutkowska, M. ; Olinger, E. ; Debaix, H. ; Seghers, F. ; Janas, S. ; Vallon, V. ; Devuyst, O.

In: Pflügers Archiv - European Journal of Physiology, 2014, vol. 466, no. 11, p. 2035-2047

Dopamine transporter (DAT) knockdown in the nucleus accumbens improves anxiety- and depression-related behaviors in adult mice

Bahi, Amine ; Dreyer, Jean-Luc

In: Behavioural Brain Research, 2019, vol. 359, p. 104–115

Many epidemiological and clinical studies have demonstrated a strong comorbidity between anxiety and depression, and a number of experimental studies indicates that the dopamine transporter (DAT) is involved in the pathophysiology of anxiety and depression. However, studies using laboratory animals have yielded inconclusive results. The aim of the present study was to examine the effects of...

Lentiviral-mediated let-7d microRNA overexpression induced anxiolytic- and anti-depressant-like behaviors and impaired dopamine D3 receptor expression

Bahi, Amine ; Dreyer, Jean-Luc

In: European Neuropsychopharmacology, 2018, vol. 28, no. 12, p. 1394–1404

Generalized anxiety and major depression disorders (MDD) are severe debilitating mood disorders whose etiology are not fully understood, but growing evidence indicates that microRNAs (miRNAs) might play a key role in their neuropathophysiological mechanisms. In the current study, we investigate the role of Lethal-7 (let-7d) miRNA, and its direct target dopamine D3 receptor (D3R) gain-of-...