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Université de Fribourg

T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field

Sanz‑Ortega, Laura ; Rojas, José M. ; Marcos, Ana ; Portilla, Yadileiny ; Stein, Jens V. ; Barber, Domingo F.

In: Journal of Nanobiotechnology, 2019, vol. 17, no. 1, p. 14

T lymphocytes are highly dynamic elements of the immune system with a tightly regulated migration. T cell-based transfer therapies are promising therapeutic approaches which in vivo efficacy is often limited by the small proportion of administered cells that reaches the region of interest. Manipulating T cell localisation to improve specific targeting will increase the effectiveness of these...

Université de Neuchâtel

Isotope fractionation due to diffusion and sorption of chlorinated hydrocarbons and its implications for identifying reactive processes in aquifer - aquitard systems

Wanner, Philipp ; Hunkeler, Daniel (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2016.

Des méthodes isotopiques stables ont été utilisées de plus en plus pour identifier et quantifier la transformation réactive dans la sous-surface de composés organiques tels que les hydrocarbures chlorés. La méthode générale repose sur l'hypothèse que seuls les processus réactifs sont associés à un effet isotopique. Cependant, des études récentes ont révélé que les processus...

Université de Neuchâtel

Action selectors without Floer-Homology

Haug, Carsten ; Schlenk, Felix (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Les systèmes hamiltoniens sur des variétés symplectiques ont d'habitude beaucoup d'orbites périodiques. Les actions des orbites forment un invariant du système hamiltonien. Cependant, l'ensemble des actions peut être très grand. Pour obtenir des invariants utiles, on ne sélectionne pour chaque fonction hamiltonienne qu'une valeur d'action en utilisant une procédure de minimax : on...

Université de Neuchâtel

On reducing latency in geo-distributed systems through state partitioning and caching

Halalai, Raluca ; Felber, Pascal (Dir.)

Thèse de doctorat : Université de Neuchâtel, 2018.

Les systèmes distribués modernes sont de plus en plus grands, et sont déployés dans plusieurs régions géographiques. L’objectif final de tels systèmes est de fournir des services à leurs utilisateurs ainsi que haute disponibilité et bonne performance. Cette thèse propose des techniques pour réduire le latence perçue par des utilisateurs. Pour commencer, nous...

Université de Fribourg

Complexities in financial network topological dynamics: modeling of emerging and developed stock markets

Tang, Yong ; Xiong, Jason Jie ; Jia, Zi-Yang ; Zhang, Yi-Cheng

In: Complexity, 2018, p. -

Policy makings and regulations of financial markets rely on a good understanding of the complexity of financial markets. There have been recent advances in applying data-driven science and network theory into the studies of social and financial systems. Financial assets and institutions are strongly connected and influence each other. It is essential to study how the topological structures of...

Université de Fribourg

Influencers identification in complex networks through reaction-diffusion dynamics

Iannelli, Flavio ; Mariani, Manuel S. ; Sokolov, Igor M.

In: Physical Review E, 2018, vol. 98, no. 6, p. 062302

A pivotal idea in network science, marketing research, and innovation diffusion theories is that a small group of nodes—called influencers—have the largest impact on social contagion and epidemic processes in networks. Despite the long-standing interest in the influencers identification problem in socioeconomic and biological networks, there is not yet agreement on which is the best...

Université de Fribourg

Empirical paths to the spread of information in location-based social networks

Zhou, Ming-Yang ; Xiong, Wen-Man ; Liao, Hao ; Wang, Tong ; Wei, Zong-Wen

In: Journal of Statistical Mechanics: Theory and Experiment, 2018, vol. 2018, no. 12, p. 123404

Spreading phenomena in complex networks have attracted much attention in recent years. However, most of the previous works only concern the critical thresholds and final states of the spread. In this paper, we investigate the empirical spreading paths in real location-based networks and find an abnormal phenomenon that the transferring probability of an epidemic between users varies with...

Université de Fribourg

Social signature identification of dynamical social networks

Li, Ren-De ; Liu, Jian-Guo ; Guo, Qiang ; Zhang, Yi-Cheng

In: Physica A: Statistical Mechanics and its Applications, 2018, vol. 508, p. 213–222

Understanding the social relation of dynamical online social networks (OSNs) is significant for identifying the strong and weak ties. In this paper, we empirically investigate the evolution characteristics of Facebook and Wiki users’ social signature, capturing the distribution of frequency of interactions between different alters over time in ego network. The statistical results show that...

Université de Fribourg

Structure-oriented prediction in complex networks

Ren, Zhuo-Ming ; Zeng, An ; Zhang, Yi-Cheng

In: Physics Reports, 2018, vol. 750, p. 1–51

Complex systems are extremely hard to predict due to its highly nonlinear interactions and rich emergent properties. Thanks to the rapid development of network science, our understanding of the structure of real complex systems and the dynamics on them has been remarkably deepened, which meanwhile largely stimulates the growth of effective prediction approaches on these systems. In this...

Université de Fribourg

Near-surface ventilation as a key for modeling the thermal regime of coarse blocky rock glaciers

Pruessner, Luisa ; Phillips, Marcia ; Farinotti, Daniel ; Hoelzle, Martin ; Lehning, Michael

In: Permafrost and Periglacial Processes, 2018, vol. 29, no. 3, p. 152–163

In a changing climate, ice‐rich permafrost features such as rock glaciers will experience drastic changes. Modeling the heat transport through the blocky surface layer with its large interstitial pore spaces poses some challenges as various modes of non‐conductive heat transport—advective forms in particular—can occur. Here, we show that the 1D physics‐based model SNOWPACK can be...