Université de Fribourg

Vitamin C promotes pluripotency of human induced pluripotent stem cells via the histone demethylase JARID1A

Eid, Wassim ; Abdel-Rehim, Wafaa

In: Biological Chemistry, 2016, vol. 397, no. 11, p. 1205-1213

Somatic cells can be reprogramed into induced pluripotent stem (iPS) cells by defined factors, which provide a powerful basis for personalized stem-cell based therapies. However, cellular reprograming is an inefficient and metabolically demanding process commonly associated with obstacles that hamper further use of this technology. Spontaneous differentiation of iPS cells cultures represents...