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Università della Svizzera italiana

The protein disulfide isomerase ERp57 regulates the steady-state levels of the prion protein

Torres, Mauricio ; Medinas,Danilo B. ; Matamala, José Manuel ; Woehlbier, Ute ; Cornejo, Víctor Hugo ; Solda, Tatiana ; Andreu, Catherine ; Rozas, Pablo ; Matus, Soledad ; Muñoz, Natalia ; Vergara, Carmen ; Cartier, Luis ; Soto, Claudio ; Molinari, Maurizio ; Hetz, Claudio

In: The journal of biological chemistry, 2015, vol. 290, no. 39, p. 23631-23645

Although the accumulation of a misfolded and protease-resistant form of the prion protein (PrP) is a key event in Prion pathogenesis, the cellular factors involved in its folding and quality control are poorly understood. PrP is a glycosylated and disulfide-bonded protein synthesized at the endoplasmic reticulum (ER). The ER foldase ERp57 (also known as Grp58) is highly expressed in the brain...

Université de Fribourg

The cuticle mutant eca2 modifies plant defense responses to biotrophic and necrotrophic pathogens and herbivory insects

Blanc, Catherine ; Coluccia, Fania ; L?Haridon, Floriane ; Torres, Martha ; Ortiz-Berrocal, Marlene ; Stahl, Elia ; Reymond, Philippe ; Schreiber, Lukas ; Nawrath, Christiane ; Métraux, Jean-Pierre ; Serrano, Mario

In: Molecular Plant-Microbe Interactions, 2017, vol. 31, no. 3, p. 344–355

We isolated previously several Arabidopsis thaliana mutants with constitutive expression of the early microbe-associated molecular pattern–induced gene ATL2, named eca (expresión constitutiva de ATL2). Here, we further explored the interaction of eca mutants with pest and pathogens. Of all eca mutants, eca2 was more resistant to a fungal pathogen (Botrytis cinerea) and a bacterial pathogen...

Université de Fribourg

TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1

Moreno-Torres, Marta ; Jaquenoud, Malika ; Péli-Gulli, Marie-Pierre ; Nicastro, Raffaele ; Virgilio, Claudio De

In: Cell Discovery, 2017, vol. 3, p. 17012

Eukaryotic cell cycle progression through G1–S is driven by hormonal and growth- related signals that are transmitted by the target of rapamycin complex 1 (TORC1) pathway. In yeast, inactivation of TORC1 restricts G1–S transition due to the rapid clearance of G1 cyclins (Cln) and the stabilization of the B-type cyclin (Clb) cyclin- dependent kinase (CDK) inhibitor Sic1. The latter mechanism...

Consortium of Swiss Academic Libraries

Total eclipse of the heart: the AM CVn Gaia14aae/ASSASN-14cn

Campbell, H. C. ; Marsh, T. R. ; Fraser, M. ; Hodgkin, S. T. ; de Miguel, E. ; Gänsicke, B. T. ; Steeghs, D. ; Hourihane, A. ; Breedt, E. ; Littlefair, S. P. ; Koposov, S. E. ; Wyrzykowski, Ł. ; Altavilla, G. ; Blagorodnova, N. ; Clementini, G. ; Damljanovic, G. ; Delgado, A. ; Dennefeld, M. ; Drake, A. J. ; Fernández-Hernández, J. ; Gilmore, G. ; Gualandi, R. ; Hamanowicz, A. ; Handzlik, B. ; Hardy, L. K. ; Harrison, D. L. ; Iłkiewicz, K. ; Jonker, P. G. ; Kochanek, C. S. ; Kołaczkowski, Z. ; Kostrzewa-Rutkowska, Z. ; Kotak, R. ; van Leeuwen, G. ; Leto, G. ; Ochner, P. ; Pawlak, M. ; Palaversa, L. ; Rixon, G. ; Rybicki, K. ; Shappee, B. J. ; Smartt, S. J. ; Torres, M. A. P. ; Tomasella, L. ; Turatto, M. ; Ulaczyk, K. ; van Velzen, S. ; Vince, O. ; Walton, N. A. ; Wielgórski, P. ; Wevers, T. ; Whitelock, P. ; Yoldas, A. ; De Angeli, F. ; Burgess, P. ; Busso, G. ; Busuttil, R. ; Butterley, T. ; Chambers, K. C. ; Copperwheat, C. ; Danilet, A. B. ; Dhillon, V. S. ; Evans, D. W. ; Eyer, L. ; Froebrich, D. ; Gomboc, A. ; Holland, G. ; Holoien, T. W.-S ; Jarvis, J. F. ; Kaiser, N. ; Kann, D. A. ; Koester, D. ; Kolb, U. ; Komossa, S. ; Magnier, E. A. ; Mahabal, A. ; Polshaw, J. ; Prieto, J. L. ; Prusti, T. ; Riello, M. ; Scholz, A. ; Simonian, G. ; Stanek, K. Z. ; Szabados, L. ; Waters, C. ; Wilson, R. W.

In: Monthly Notices of the Royal Astronomical Society, 2015, vol. 452, no. 1, p. 1060-1067

Université de Fribourg

TORC1 controls G1-S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway

Moreno-Torres, Marta ; Jaquenoud, Malika ; De Virgilio, Claudio

In: Nature Communications, 2015, vol. 6, p. 8256

The target of rapamycin complex 1 (TORC1) pathway couples nutrient, energy and hormonal signals with eukaryotic cell growth and division. In yeast, TORC1 coordinates growth with G₁–S cell cycle progression, also coined as START, by favouring the expression of G₁ cyclins that activate cyclin-dependent protein kinases (CDKs) and by destabilizing the CDK inhibitor Sic1. Following TORC1...

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