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EF-hand protein Ca²⁺ buffers regulate Ca²⁺ influx and exocytosis in sensory hair cells

Pangršič, Tina ; Gabrielaitis, Mantas ; Michanski, Susann ; Schwaller, Beat ; Wolf, Fred ; Strenzke, Nicola ; Moser, Tobias

In: Proceedings of the National Academy of Sciences, 2015, vol. 112, no. 9, p. E1028–E1037

EF-hand Ca²⁺-binding proteins are thought to shape the spatiotemporal properties of cellular Ca²⁺ signaling and are prominently expressed in sensory hair cells in the ear. Here, we combined genetic disruption of parvalbumin-α, calbindin-D28k, and calretinin in mice with patch-clamp recording, in vivo physiology, and mathematical modeling to study their role in Ca²⁺ signaling,...